J
Jason G. Cyster
Researcher at University of California, San Francisco
Publications - 214
Citations - 46949
Jason G. Cyster is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: B cell & Germinal center. The author has an hindex of 106, co-authored 199 publications receiving 42370 citations. Previous affiliations of Jason G. Cyster include London Research Institute & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Structure of S1PR2–heterotrimeric G13 signaling complex
TL;DR: The cryo–electron microscopy structure of S1P-bound S1PR2 coupled to the heterotrimeric G13 illuminates the mechanism of receptor disruption by disease-associated mutations and reveals a basis for S 1PR drug selectivity.
Journal ArticleDOI
Marginal zone SIGN-R1+ macrophages are essential for the maturation of germinal center B cells in the spleen.
TL;DR: A previously unappreciated role for SIGN-R1+ macrophages in regulation of the GC reaction is revealed and this study highlights the functional specification of macrophage subsets in the MZ compartment.
Journal ArticleDOI
GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein.
Jing Cheng,Linda R. Klei,Nathaniel E Hubel,Ming Zhang,Rebekka Schairer,Lisa M. Maurer,Hanna B. Klei,Heejae Kang,Vincent J. Concel,Phillip C. Delekta,Eric V. Dang,Michelle A. Mintz,Mathijs Baens,Jason G. Cyster,Narayanan Parameswaran,Margot Thome,Peter C. Lucas,Linda M. McAllister-Lucas +17 more
TL;DR: G protein-coupled receptor kinase 2 (GRK2) is identified as a new MALT1-interacting protein and it is suggested that GRK2 can function as a tumor suppressor by inhibiting Malt1 and provide a roadmap for developing new strategies to inhibit MALT 1-dependent lymphomagenesis.
Patent
Modulating the interaction of the chemokine, B Lymphocyte Hemoattractant, and its Receptor, BLR1
TL;DR: In this paper, the authors provide methods for identifying agents which modulate the interaction of a chemokine receptor of previously unknown function, Burkitt's Lymphoma Receptor 1 (BLR1), with its ligand, B Lymphocyte Chemoattractant (BLC).