J
Jason G. Cyster
Researcher at University of California, San Francisco
Publications - 214
Citations - 46949
Jason G. Cyster is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: B cell & Germinal center. The author has an hindex of 106, co-authored 199 publications receiving 42370 citations. Previous affiliations of Jason G. Cyster include London Research Institute & Howard Hughes Medical Institute.
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Journal ArticleDOI
Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.
Richard J. Cornall,Jason G. Cyster,Margaret L. Hibbs,Ashley R. Dunn,Kevin L. Otipoby,Edward A. Clark,Christopher C. Goodnow +6 more
TL;DR: As in invertebrates, genetic effects of loci with only one functional allele can be used to analyze signaling networks in mice, demonstrating that negative regulation of the BCR is a complex quantitative trait in which Lyn, the coreceptor CD22, and the tyrosine phosphatase SHP-1 are each limiting elements.
Journal ArticleDOI
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.
Trung H.M. Pham,Peter Baluk,Ying Xu,Irina L. Grigorova,Alexander J. Bankovich,Rajita Pappu,Shaun R. Coughlin,Donald M. McDonald,Susan R. Schwab,Jason G. Cyster +9 more
TL;DR: Evidence is provided that lymphatic endothelial cells are an in vivo source of S1P required for lymphocyte egress from LNs and Peyer's patches, and a role for S1p in lymphatic vessel maturation is suggested.
Journal ArticleDOI
S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress
TL;DR: It is shown that C CR7-deficient T cells left lymph nodes more rapidly than wild-type cells did, whereas CCR7-overexpressing cells were retained for longer.
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Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
Guy Cinamon,Mehrdad Matloubian,Matthew J. Lesneski,Ying Xu,Caroline Low,Theresa T. Lu,Theresa T. Lu,Richard L. Proia,Jason G. Cyster +8 more
TL;DR: It is reported that FTY720, a drug that targets sphingosine 1-phosphate (S1P) receptors, induced marginal zone B cell migration into follicles, and using gene-targeted mice, it is shown that S1P1 but not S1p3 was required for localization in the marginal zone.
Journal ArticleDOI
Integrin-mediated long-term B cell retention in the splenic marginal zone.
Theresa T. Lu,Jason G. Cyster +1 more
TL;DR: Key requirements for MZ B cell localization are identified and a role for integrins in peripheral lymphoid tissue compartmentalization is established and down-regulation of integrin-mediated adhesion is established.