J
Jason G. Cyster
Researcher at University of California, San Francisco
Publications - 214
Citations - 46949
Jason G. Cyster is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: B cell & Germinal center. The author has an hindex of 106, co-authored 199 publications receiving 42370 citations. Previous affiliations of Jason G. Cyster include London Research Institute & Howard Hughes Medical Institute.
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Journal ArticleDOI
Visualization of the genesis and fate of isotype-switched B cells during a primary immune response.
Kathryn A. Pape,Valerie Kouskoff,David Nemazee,H. Lucy Tang,Jason G. Cyster,Lina E. Tze,Keli L. Hippen,Timothy W. Behrens,Marc K. Jenkins +8 more
TL;DR: A small population of B cells carrying targeted antibody transgenes capable of class switching was monitored in immunized mice, finding that some of the switched B cells transiently occupied the red pulp and marginal zone, whereas others persisted in germinal centers (GCs).
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Germinal centers: programmed for affinity maturation and antibody diversification
Oliver Bannard,Jason G. Cyster +1 more
TL;DR: Current understanding of how germinal centers are programmed to support both affinity maturation and antibody diversification is discussed.
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Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure
TL;DR: A mathematical model of T-cell egress from LNs is developed and suggests that random walk encounters with lymphatic sinuses are the major factor contributing to LN transit times.
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B cell migration and interactions in the early phase of antibody responses
Takaharu Okada,Jason G. Cyster +1 more
TL;DR: These studies have provided a more detailed map of the steps involved in B cell migration to encounter antigen and helper T cells early during the adaptive immune response.
Journal ArticleDOI
B Cells Control the Migration of a Subset of Dendritic Cells into B Cell Follicles Via CXC Chemokine Ligand 13 in a Lymphotoxin-Dependent Fashion
Ping Yu,Yang Wang,Robert K. Chin,Luisa Martinez-Pomares,Siamon Gordon,Marie H. Kosco-Vibois,Jason G. Cyster,Yang Xin Fu +7 more
TL;DR: It is proposed that B cells play a central role in establishing the chemotactic gradient that attracts not only Ag-activated T and B cells but also Ag-carrying CR-Fc+ DCs.