J
Jason G. Cyster
Researcher at University of California, San Francisco
Publications - 214
Citations - 46949
Jason G. Cyster is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: B cell & Germinal center. The author has an hindex of 106, co-authored 199 publications receiving 42370 citations. Previous affiliations of Jason G. Cyster include London Research Institute & Howard Hughes Medical Institute.
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Journal ArticleDOI
G-protein coupled receptors and ligands that organize humoral immune responses
Erick Lu,Jason G. Cyster +1 more
TL;DR: The goal is to provide the reader with a focused knowledge about the GPCRs guiding B‐cell responses and how they might be therapeutic targets, while also providing examples of how multiple types of GPCR can cooperate or act iteratively to control cell behavior.
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Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope.
Annette Bistrup,Durwin Tsay,Priti Shenoy,Mark S. Singer,Naveen Bangia,Sanjiv A. Luther,Jason G. Cyster,Nancy H. Ruddle,Steven D. Rosen +8 more
TL;DR: In this article, an antibody against murine HEC-GlcNAc6ST was used to study its expression in relationship to the MECA-79 epitope, showing that the enzyme is responsible for the defined luminal ligands.
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FTY720 Blocks Egress of T Cells in Part by Abrogation of Their Adhesion on the Lymph Node Sinus
Liang Zhi,Pilhan Kim,Brian Thompson,Costas Pitsillides,Alexander J. Bankovich,Seok Hyun Yun,Charles P. Lin,Jason G. Cyster,Mei X. Wu +8 more
TL;DR: It is argued for the first time, to the authors' knowledge, that FTY720 induces lymphopenia in part by impairing T cell adhesion to the sinus in a manner dependent on Gαi2.
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The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination.
TL;DR: The orphan Gα13-coupled receptor P2RY8 promotes clustering of B cells at the follicle center in an FDC-dependent manner and Egress of G α13 or Arhgef1 mutant GC B cells into circulation depends on the function of the promigratory receptor S1pr3.
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B cells within germinal centers migrate preferentially from dark to light zone
TL;DR: This work reanalyzes a previously published dataset on GC B-cell migration, applying a sensitive analysis technique to detect directed migration and using a procedure to correct for a number of artifacts that frequently occur in time-lapse imaging experiments.