J
Jason G. Cyster
Researcher at University of California, San Francisco
Publications - 214
Citations - 46949
Jason G. Cyster is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: B cell & Germinal center. The author has an hindex of 106, co-authored 199 publications receiving 42370 citations. Previous affiliations of Jason G. Cyster include London Research Institute & Howard Hughes Medical Institute.
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Journal ArticleDOI
Germinal Centers: Gaining Strength from the Dark Side
TL;DR: It is reported that Foxo1 deficiency causes an almost complete loss of dark zone cells and an inability to undergo robust antibody affinity maturation.
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Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.
Carlos A. Castellanos,Xin Ren,Steven Lomeli Gonzalez,Hong Kun Li,Andrew Schroeder,Hong-Erh Liang,Brian J. Laidlaw,Donglei Hu,Angel C.Y. Mak,Celeste Eng,Jose R. Rodriguez-Santana,Michael A. LeNoir,Qi Yan,Juan C. Celedón,Esteban G. Burchard,Scott S. Zamvil,Satoshi Ishido,Richard M. Locksley,Jason G. Cyster,Xiaozhu Huang,Jeoung-Sook Shin +20 more
TL;DR: Type 2 T helper (TH2) cells are protective against parasitic worm infections but also aggravate allergic inflammation as mentioned in this paper, although the role of dendritic cells (DCs) in TH2 cell differentiation is well-known.
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Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen *
TL;DR: This review considers the insights into cDC function in the spleen that have emerged from imaging studies and discusses the contribution of chemoattractant receptors (EBI2 or GPR183, S1PR1, and CCR7) and integrins to cDC2 positioning and function.
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Thymic egress: S1P of 1000.
TL;DR: This work has generated immediate translational impact, aiding the design of immunosuppressant drugs and the identification of a novel form of human immunodeficiency.
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An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells
Simona Ceglia,Alyssa Berthelette,Kelsey Howley,Yun Li,Benedikt M Mortzfeld,Shakti K. Bhattarai,Nicole K.H. Yiew,Ying Xu,R. Brink,Jason G. Cyster,Lora V. Hooper,Gwendalyn J. Randolph,Vanni Bucci,Andrea Reboldi +13 more