J
Jason G. Cyster
Researcher at University of California, San Francisco
Publications - 214
Citations - 46949
Jason G. Cyster is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: B cell & Germinal center. The author has an hindex of 106, co-authored 199 publications receiving 42370 citations. Previous affiliations of Jason G. Cyster include London Research Institute & Howard Hughes Medical Institute.
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Journal ArticleDOI
Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin.
TL;DR: The Laidlaw et al. find that the migration inhibitory S1PR2 receptor cooperates with CD69 to promote the retention of IL-17–producing γδ T cells within the dermis.
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Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells.
Karin Schaeuble,Mirjam R. Britschgi,Leo Scarpellino,Stéphanie Favre,Ying Xu,Ekaterina P. Koroleva,Tonje Katrine A. Lissandrin,Alexander Link,Mehrdad Matloubian,Carl F. Ware,Sergei A. Nedospasov,Alexei V. Tumanov,Jason G. Cyster,Sanjiv A. Luther +13 more
TL;DR: It is proposed that WP development proceeds in multiple steps, with LTα1β2+ B cells acting as major inducer cells driving the expansion and gradual differentiation of perivascular fibroblasts into T and B zone organizer cells.
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Loss of sterol metabolic homeostasis triggers inflammasomes — how and why
Eric V. Dang,Jason G. Cyster +1 more
TL;DR: How clues from human genetics have led to new insights into how alterations in isoprenoid biosynthesis connect to inflammation are discussed and new mechanisms that show how macrophage cholesterol buildup can lead to inflammasome activation are discussed.
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The C2H2-ZF transcription factor Zfp335 recognizes two consensus motifs using separate zinc finger arrays
TL;DR: Zfp335 is presented as a model for understanding how C2H2-ZF TFs may use multiple recognition motifs to control gene expression and binds DNA and drives transcription via recognition of two distinct consensus motifs by separate ZF clusters.
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G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment.
Hayakazu Sumida,Jason G. Cyster +1 more
TL;DR: A novel GPCR requirement for establishment or maintenance of the CD8 KLRG1+ effector-memory T cell compartment is described and implications for methods to augment CD8 effector cell numbers are described.