J
Jason G. Cyster
Researcher at University of California, San Francisco
Publications - 214
Citations - 46949
Jason G. Cyster is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: B cell & Germinal center. The author has an hindex of 106, co-authored 199 publications receiving 42370 citations. Previous affiliations of Jason G. Cyster include London Research Institute & Howard Hughes Medical Institute.
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Journal ArticleDOI
Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma
Jagan R. Muppidi,Roland Schmitz,Jesse A. Green,Jesse A. Green,Wenming Xiao,Adrien B. Larsen,Sterling E. Braun,Jinping An,Ying Xu,Andreas Rosenwald,German Ott,Randy D. Gascoyne,Lisa M. Rimsza,Elias Campo,Elaine S. Jaffe,Jan Delabie,Erlend B. Smeland,Rita M. Braziel,Raymond R. Tubbs,James R. Cook,Dennis D. Weisenburger,Wing C. Chan,Nagarajan Vaidehi,Louis M. Staudt,Jason G. Cyster +24 more
TL;DR: It is shown that GCB-DLBCL-associated mutations occurring in S1PR2 frequently disrupt the receptor’s Akt and migration inhibitory functions, and a Gα13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells is identified.
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IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches
TL;DR: The hypothesis that CCR6 expression in PP B cells is necessary for their efficient switching to IgA and for production of intestinal IgA against cholera toxin and commensal bacteria is pursued.
Journal ArticleDOI
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.
Jeffrey D. Whitman,Joseph Hiatt,Cody T. Mowery,Brian R. Shy,Ruby Yu,Tori N. Yamamoto,Ujjwal Rathore,Gregory M. Goldgof,Caroline Whitty,Jonathan M. Woo,Jonathan M. Woo,Antonia E. Gallman,Tyler E. Miller,Andrew G. Levine,David N. Nguyen,David N. Nguyen,Sagar P. Bapat,Joanna Balcerek,Sophia A. Bylsma,Ana M. Lyons,Stacy Li,Allison W. Wong,Eva M. Gillis-Buck,Zachary Steinhart,Youjin Lee,Ryan Apathy,Ryan Apathy,Mitchell J. Lipke,Jennifer A Smith,Tina Zheng,Ian C. Boothby,Erin Isaza,Jackie Chan,Dante D. Acenas,Jinwoo Lee,Trisha A. Macrae,Than S. Kyaw,David Wu,Dianna Ng,Wei Gu,Vanessa A. York,Haig A. Eskandarian,Perri C. Callaway,Perri C. Callaway,Lakshmi Warrier,Mary E. Moreno,Justine Levan,Leonel Torres,Lila A. Farrington,Rita P. Loudermilk,Kanishka Koshal,Kelsey C. Zorn,Wilfredo F. Garcia-Beltran,Diane Yang,Michael G Astudillo,Bradley E. Bernstein,Jeffrey A. Gelfand,Edward T. Ryan,Richelle C. Charles,A. John Iafrate,Jochen K. Lennerz,Steve Miller,Charles Y. Chiu,Susan L. Stramer,Michael R. Wilson,Aashish Manglik,Chun Jimmie Ye,Nevan J. Krogan,Nevan J. Krogan,Mark S. Anderson,Jason G. Cyster,Joel D. Ernst,Alan H.B. Wu,Kara L. Lynch,Caryn Bern,Patrick D. Hsu,Alexander Marson +76 more
TL;DR: A head-to-head evaluation of ten point-of-care-style lateral flow assays and two laboratory-based enzyme-linked immunosorbent assays to detect anti-SARS-CoV-2 IgM and IgG antibodies in 5-d time intervals from symptom onset underline the importance of seropositivity threshold determination and reader training for reliable LFA deployment.
Journal ArticleDOI
Cutting Edge: Differential Roles for Phosphoinositide 3-Kinases, p110γ and p110δ, in Lymphocyte Chemotaxis and Homing
Karin Reif,Klaus Okkenhaug,Takehiko Sasaki,Joseph M. Penninger,Bart Vanhaesebroeck,Jason G. Cyster +5 more
TL;DR: It is reported that p110γ and p110δ function in lymphocyte chemotaxis, and differential roles for PI3K family members in B and T cell migration are shown.
Journal ArticleDOI
The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement
Jesse A. Green,Kazuhiro Suzuki,Kazuhiro Suzuki,Bryan Cho,Bryan Cho,L David Willison,L David Willison,Daniel Palmer,Christopher D.C. Allen,Christopher D.C. Allen,Timothy H. Schmidt,Ying Xu,Richard L. Proia,Shaun R. Coughlin,Jason G. Cyster +14 more
TL;DR: It is suggested that by inhibiting Akt activation and migration, S1P2 helps restrict GC B cell survival and localization to an S 1P-low niche at the follicle center.