J
Jason G. Cyster
Researcher at University of California, San Francisco
Publications - 214
Citations - 46949
Jason G. Cyster is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: B cell & Germinal center. The author has an hindex of 106, co-authored 199 publications receiving 42370 citations. Previous affiliations of Jason G. Cyster include London Research Institute & Howard Hughes Medical Institute.
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Journal ArticleDOI
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis
Thomas T. Chen,Li Li,Dong-Hui Chung,Christopher D.C. Allen,Suzy V. Torti,Frank M. Torti,Jason G. Cyster,Chih-Ying Chen,Frances M. Brodsky,Eréne C. Niemi,Mary C. Nakamura,Mary C. Nakamura,William E. Seaman,William E. Seaman,Michael R. Daws,Michael R. Daws +15 more
TL;DR: It is demonstrated that mouse TIM-2 is a receptor for H-ferritin, but not for L-ferrisin, and expression of TIM-1 permits the cellular uptake of H- Ferritin into endosomes, which is the first identification of a receptors for ferritin and reveals a new role for Tim-2.
Journal ArticleDOI
Peyer's patches: organizing B-cell responses at the intestinal frontier
Andrea Reboldi,Jason G. Cyster +1 more
TL;DR: Current understanding of how PPs foster B‐cell encounters with antigen is reviewed, how they favor isotype switching to the secretory IgA isotype, and how their GC responses may uniquely contribute to mucosal immunity are reviewed.
Journal ArticleDOI
Homing of antibody secreting cells.
TL;DR: This review discusses the chemokines involved in directing ASC movements, particularly focusing on the role of CXCR4 and CXCL12/SDF1.
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How T Cells Earn the Follicular Rite of Passage
TL;DR: Improved reagents and recent models that allow tracking of Bcl-6-expressing T cells have revealed that the decision to become a Tfh cell occurs soon after T cells are primed by dendritic cells and start dividing, before interaction with B cells.
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Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress
TL;DR: It is shown that marginal zone B cells migrate continually between marginal zone and follicles and establishes the marginal zone as a site of S1PR1-dependent B-cell exit from follicles, and how adhesive differences of similar cells critically influence their behaviour in the same microenvironment is shown.