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Jason P. Berninger

Researcher at United States Geological Survey

Publications -  35
Citations -  2293

Jason P. Berninger is an academic researcher from United States Geological Survey. The author has contributed to research in topics: Environmental exposure & Oil dispersants. The author has an hindex of 20, co-authored 33 publications receiving 1925 citations. Previous affiliations of Jason P. Berninger include Baylor University & United States Environmental Protection Agency.

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Human Therapeutic Plasma Levels of the Selective Serotonin Reuptake Inhibitor (SSRI) Sertraline Decrease Serotonin Reuptake Transporter Binding and Shelter-Seeking Behavior in Adult Male Fathead Minnows

TL;DR: In this article, Sertraline was selected as a model SSRI for a 28-d study with adult male fathead minnows and the binding activity of the serotonin reuptake transporter (SERT) was used as an endpoint associated with therapeutic activity.
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Effects of the antihistamine diphenhydramine on selected aquatic organisms

TL;DR: Results from both acute mortality and subchronic reproduction studies indicated that the model aquatic invertebrate, Daphnia magna, was more sensitive to DPH than the fish model, suggesting that DPH may exert toxicity in Daphnian through ACh and histamine MOAs.
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Leveraging mammalian pharmaceutical toxicology and pharmacology data to predict chronic fish responses to pharmaceuticals.

TL;DR: Using a probabilistic hazard evaluation approach, rodent and fish acute toxicity distributions predicted limited potential for acute toxicity at low concentrations, which is consistent with the peer-reviewed literature.
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Molecular target sequence similarity as a basis for species extrapolation to assess the ecological risk of chemicals with known modes of action.

TL;DR: This work describes a strategy that leverages expanding databases of molecular sequence information together with identification of specific molecular chemical targets whose perturbation can lead to adverse outcomes to support predictive species extrapolation.