J
Jean-Louis Romette
Researcher at Centre national de la recherche scientifique
Publications - 30
Citations - 1611
Jean-Louis Romette is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: RNA-dependent RNA polymerase & RNA polymerase. The author has an hindex of 15, co-authored 30 publications receiving 1515 citations. Previous affiliations of Jean-Louis Romette include Aix-Marseille University & University of Provence.
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Journal ArticleDOI
An RNA cap (nucleoside‐2′‐O‐)‐methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
TL;DR: The results provide a structural basis for the rational design of drugs against the emerging flaviviruses and suggest that the latter is a specific cap‐binding site.
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The flavivirus polymerase as a target for drug discovery
Hélène Malet,Nicolas Massé,Barbara Selisko,Jean-Louis Romette,Karine Alvarez,Jean-Claude Guillemot,Hughes Tolou,Thai Leong Yap,Thai Leong Yap,Subash G. Vasudevan,Julien Lescar,Julien Lescar,Julien Lescar,Bruno Canard +13 more
TL;DR: An overview of the current knowledge regarding Flavivirus RdRp function and structure is given as it represents an attractive target for drug design and ongoing approaches of in vitro and cell-based screening programs aiming at the discovery of nucleosidic and non-nucleosidics inhibitors targeting Flaviv virus RdRps are reviewed.
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The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.
Delphine Benarroch,Barbara Selisko,Giada A. Locatelli,Giovanni Maga,Jean-Louis Romette,Bruno Canard +5 more
TL;DR: DV RTPase seems to belong to a new class of Mg2+-dependent RTPases, which use the active center of the helicase/NTPase catalytic core in conjunction with elements in the C-terminal domain.
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A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.
Delphine Benarroch,Marie-Pierre Egloff,Laurence A. Mulard,Catherine Guerreiro,Jean-Louis Romette,Bruno Canard +5 more
TL;DR: Detailed atomic interactions provide the first structural insights into the inhibition of a viral enzyme by ribavirin 5′-triphosphate, as well as the basis for rational drug design of antiviral agents with improved specificity against the emerging flaviviruses.
Journal ArticleDOI
Purification of GSK-3 by affinity chromatography on immobilized axin
Aline Primot,Blandine Baratte,Marie Gompel,Annie Borgne,Sylvie Liabeuf,Jean-Louis Romette,Eek-hoon Jho,Frank Costantini,Laurent Meijer +8 more
TL;DR: This single step purification method provides a convenient tool to follow the status of GSK-3 (protein level, phosphorylation state, kinase activity) under various physiological settings and provides a simple and efficient way to purify large amounts of active recombinant or native G SK-3 for screening purposes.