P
Pedro J. Real
Researcher at University of Granada
Publications - 70
Citations - 5027
Pedro J. Real is an academic researcher from University of Granada. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 25, co-authored 59 publications receiving 4595 citations. Previous affiliations of Pedro J. Real include Columbia University.
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Journal ArticleDOI
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
Teresa Palomero,Maria Luisa Sulis,Maria Cortina,Pedro J. Real,Kelly Barnes,Maria Ciofani,Esther Caparrós,Jean Buteau,Kristy A. Brown,Sherrie L. Perkins,Govind Bhagat,Archana M. Agarwal,Giuseppe Basso,Mireia Castillo,Satoru Nagase,Carlos Cordon-Cardo,Ramon Parsons,Juan Carlos Zúñiga-Pflücker,Maria Dominguez,Adolfo A. Ferrando +19 more
TL;DR: Findings identify transcriptional control of PTEN and regulation of the PI3K-AKT pathway as key elements of the leukemogenic program activated by NOTCH1 and provide the basis for the design of new therapeutic strategies for T-ALL.
Journal ArticleDOI
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
Teresa Palomero,Wei Keat Lim,Duncan T. Odom,Maria Luisa Sulis,Pedro J. Real,Adam A. Margolin,Kelly Barnes,Jennifer O'Neil,Donna Neuberg,Andrew P. Weng,Jon C. Aster,François Sigaux,Jean Soulier,A. Thomas Look,Richard A. Young,Andrea Califano,Adolfo A. Ferrando +16 more
TL;DR: In this paper, the authors used an integrative systems biology approach to identify c-myc as an essential mediator of NOTCH1 signaling and integrate NOTCH 1 activation with oncogenic signaling pathways upstream of c-MYC.
Journal ArticleDOI
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Pedro J. Real,Valeria Tosello,Teresa Palomero,Teresa Palomero,Mireia Castillo,Eva Hernando,Elisa de Stanchina,Maria Luisa Sulis,Maria Luisa Sulis,Kelly Barnes,Catherine M. Sawai,Irene Homminga,Jules P.P. Meijerink,Iannis Aifantis,Giuseppe Basso,Carlos Cordon-Cardo,Weiyun Z. Ai,Adolfo A. Ferrando,Adolfo A. Ferrando +18 more
TL;DR: It is shown that combination therapy with GSIs plus glucocorticoids can improve the antileukemic effects of GSIs and reduce their gut toxicity in vivo and support a role for glucocORTicoid-resistant T-ALL.
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Human Induced Pluripotent Stem Cells Develop Teratoma More Efficiently and Faster Than Human Embryonic Stem Cells Regardless the Site of Injection
Ivan Gutierrez-Aranda,Verónica Ramos-Mejía,Clara Bueno,Martin Muñoz-Lopez,Pedro J. Real,Angela Macia,Laura Sánchez,Gertrudis Ligero,Jose L. Garcia‐Parez,Pablo Menendez +9 more
TL;DR: The improved teratoma protocol previously developed by Prokhorova et al. was followed and fully characterized undifferentiated hESCs or iPSCs were used in 6- to 8-week-old non obese diabetic/severe combined immune-deficient mice, ensuring a longer lifespan of inoculated mice.
Journal ArticleDOI
Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells.
Pedro J. Real,Angels Sierra,Ana de Juan,José C. Segovia,Jose M. Lopez-Vega,Jose L. Fernandez-Luna +5 more
TL;DR: The data suggest that an increased activation of the Stat3–Bcl-2 pathway in estrogen receptor-negative metastatic breast cancer cell lines confer a survival advantage to these cells and contribute to their chemoresistance.