J
Jens Bukh
Researcher at University of Copenhagen
Publications - 302
Citations - 22917
Jens Bukh is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 71, co-authored 270 publications receiving 21051 citations. Previous affiliations of Jens Bukh include Copenhagen University Hospital & Hvidovre Hospital.
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Patent
Cloned genomes of infectious hepatitis C viruses and uses thereof
TL;DR: The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of the sequences, in the development of vaccines and diagnostics for HCV and in the developing of screening assays for the identification of antiviral agents for hepatitis C.
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Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry.
TL;DR: The ability of HVR1 to protect HCV from NAbs appears to be linked with modulation of HCV entry co-receptor interactions, and improved E1/E2 models and comparative studies with other NAb evasion strategies are needed.
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Current status and future development of infectious cell-culture models for the major genotypes of hepatitis C virus: Essential tools in testing of antivirals and emerging vaccine strategies.
Santseharay Ramirez,Jens Bukh +1 more
TL;DR: Research aimed at identifying novel strategies that will permit universal culture of HCV will be needed to further the understanding of this unique virus causing 400 thousand deaths annually.
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Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems.
Troels K. H. Scheel,Jannick Prentoe,Thomas H. R. Carlsen,Lotte S. Mikkelsen,Judith M. Gottwein,Jens Bukh +5 more
TL;DR: This study identified NS5A genetic elements essential for all major HCV genotypes in infectious cell culture systems, and demonstrated a universal importance of the amphipathic alpha-helix, domain I and II and the low-complexity sequence (LCS) I for HCV replication.
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Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations.
Jannick Prentoe,Rodrigo Velázquez-Moctezuma,Elias H. Augestad,Elias H. Augestad,Andrea Galli,Andrea Galli,Richard J. Wang,Mansun Law,Harvey J. Alter,Jens Bukh,Jens Bukh +10 more
TL;DR: It is found that HVR1 and glycans regulate HCV neutralization by shifting the equilibrium between open and closed envelope conformations, suggesting a role of this receptor in transitions from closed to open conformations during entry.