J
Jens Bukh
Researcher at University of Copenhagen
Publications - 302
Citations - 22917
Jens Bukh is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 71, co-authored 270 publications receiving 21051 citations. Previous affiliations of Jens Bukh include Copenhagen University Hospital & Hvidovre Hospital.
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Journal ArticleDOI
Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain.
Thomas Vanwolleghem,Jens Bukh,Jens Bukh,Jens Bukh,Philip Meuleman,Isabelle Desombere,Jean-Christophe Meunier,Jean-Christophe Meunier,Harvey J. Alter,Robert H. Purcell,Geert Leroux-Roels +10 more
TL;DR: Polyclonal IgG from a patient with a long‐standing HCV infection not only displays neutralizing activity in vitro using the HCVpp system, but also conveys sterilizing immunity toward the ancestral HCV strain in vivo, using the human liver–chimeric mouse model.
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Toward a surrogate model for hepatitis C virus: An infectious molecular clone of the GB virus-B hepatitis agent.
TL;DR: The development of severe hepatitis in both tamarins infected with the recombinant GBV-B virus provides formal proof that GBV -B is a true hepatitis virus.
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Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family.
B. Douglas Smith,Paul Becher,Jens Bukh,Ernest A. Gould,Gregor Meyers,Thomas P. Monath,A. Scott Muerhoff,Alexander G. Pletnev,Rebecca Rico-Hesse,Jack T. Stapleton,Jack T. Stapleton,Peter Simmonds,Peter Simmonds +12 more
TL;DR: It is proposed that the species Hepatitis C virus is renamed Hepacivirus C in order to acknowledge its unique historical position and so as to minimize confusion.
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Efficient Replication of Genotype 3a and 4a Hepatitis C Virus Replicons in Human Hepatoma Cells
Mohsan Saeed,Troels K. H. Scheel,Troels K. H. Scheel,Troels K. H. Scheel,Judith M. Gottwein,Judith M. Gottwein,Svetlana Marukian,Lynn B. Dustin,Jens Bukh,Jens Bukh,Charles M. Rice +10 more
TL;DR: These replicons were modified to express a chimeric fusion protein of firefly luciferase and neomycin phosphotransferase to yield stable replicon-expressing cells and became useful for high-throughput screening and evaluation of antiviral compounds.
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Novel Infectious cDNA Clones of Hepatitis C Virus Genotype 3a (Strain S52) and 4a (Strain ED43): Genetic Analyses and In Vivo Pathogenesis Studies
Judith M. Gottwein,Troels K. H. Scheel,Benoit Callendret,Yi-Ping Li,Heather B. Eccleston,Ronald E. Engle,Sugantha Govindarajan,William C. Satterfield,Robert H. Purcell,Christopher M. Walker,Jens Bukh,Jens Bukh +11 more
TL;DR: Genomic consensus sequences recovered from serum at the times of peak viral titers were identical to the sequences of the parental plasmids, and fully functional infectious cDNA clones of HCV genotypes 3a and 4a were generated.