J
Jens Bukh
Researcher at University of Copenhagen
Publications - 302
Citations - 22917
Jens Bukh is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 71, co-authored 270 publications receiving 21051 citations. Previous affiliations of Jens Bukh include Copenhagen University Hospital & Hvidovre Hospital.
Papers
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Journal ArticleDOI
Toward a vaccine against hepatitis C virus
TL;DR: A vaccine protecting against chronic infection with hepatitis C virus (HCV) is urgently needed to address the ongoing public health crisis caused by this insidious pathogen, a major cause of liver cirrhosis and cancer as discussed by the authors .
Journal ArticleDOI
Importance of the polymerase chain reaction in the study of hepatitis C virus infection
TL;DR: A review examines the pivotal role of the polymerase chain reaction in understanding the biology of hepatitis C virus and its role in parenterally transmitted non-A, non-B hepatitis.
Journal ArticleDOI
High-Titer Hepatitis C Virus Production in a Scalable Single-Use High Cell Density Bioreactor
Anna Offersgaard,C. R. Duarte Hernandez,Anne Finne Pihl,Nandini Venkatesan,Henrik Krarup,Xiangliang Lin,Udo Reichl,Jens Bukh,Yvonne Genzel,Judith M. Gottwein +9 more
TL;DR: This packed-bed tide-motion system is available with larger vessels and may thus be a promising platform for large-scale HCV production and to facilitate virological and immunological studies requiring large quantities of virus particles.
Journal ArticleDOI
An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals
Anna Offersgaard,C. R. Duarte Hernandez,Shan Feng,Pavel Marichal-Gallardo,Kenn Holmbeck,Anne Finne Pihl,Carlota Fernandez-Antunez,Garazi Peña Alzua,Katrine Top Hartmann,Long Vo Pham,Yuyong Zhou,Karen A. Gammeltoft,Ulrik Fahnøe,Uffe Vest Schneider,Gabriel K. Pedersen,H. E. Jensen,Jan Pravsgaard Christensen,Santseharay Ramirez,Jens Bukh,Judith M. Gottwein +19 more
TL;DR: In this paper , an inactivated SARS-CoV-2 vaccine based on a viral isolate with the Spike mutation D614G, produced in Vero cells in a scalable bioreactor, inactivated with β-propiolactone, purified by membrane-based steric exclusion chromatography, and adjuvanted with MF59-like adjuvant AddaVax.
Patent
Hcv full-length genotype 2b consensus clone
Li Yiping,Scheel Troels Kasper Hoeyer,Almeida Santseharay Ramirez,Judith M. Gottwein,Jens Bukh +4 more
TL;DR: In this article, an isolated nucleic acid molecule which encodes a human hepatitis C virus was described, wherein the hepatitisC virus is derived from genotype 2b, isolate J8CF as well as compositions, methods and uses of isolate J 8CF.