J
Jens Bukh
Researcher at University of Copenhagen
Publications - 302
Citations - 22917
Jens Bukh is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 71, co-authored 270 publications receiving 21051 citations. Previous affiliations of Jens Bukh include Copenhagen University Hospital & Hvidovre Hospital.
Papers
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Journal ArticleDOI
Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies.
TL;DR: SA13/JF470-510cc represents a model to elucidate the influence of HCV RNA elements on viral replication and map determinants of sensitivity to polymerase inhibitors and showed differential sensitivity to inhibitors targeting the NS5B palm or thumb.
Journal ArticleDOI
Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice
Garazi Peña Alzua,Anne Finne Pihl,Anna Offersgaard,C. R. Duarte Hernandez,Zhenzhen Duan,Shan Feng,Ulrik Fahnøe,Christina Sølund,Nina Weis,Mansun Law,Jannick Prentoe,Jan Pravsgaard Christensen,Jens Bukh,Judith M. Gottwein +13 more
TL;DR: High-yield genotype 1–3 HCV could be developed as basis for inactivated vaccine candidates inducing broadly neutralising antibodies in mice supporting further preclinical development.
Journal ArticleDOI
Genetic variants in 5‐HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis
Nis P. Suppli,Jens Bukh,Terrie E. Moffitt,Avshalom Caspi,Christoffer Johansen,Anne Tjønneland,Lars Vedel Kessing,Susanne Oksbjerg Dalton +7 more
TL;DR: The role of gene–environment interactions in the pathogenesis of depression is unclear and vulnerability for depression after childhood adversity and stressful life events among carriers of numerous specific genetic variants is addressed.
Patent
Nucleotide and amino acid sequences of hypervariable region 1 of the envelope 2 gene of hepatitis c virus
TL;DR: The nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of 49 isolates of hepatitis C were disclosed in this article, which relates to the use of these sequences to design proteins and nucleic acid sequences useful in diagnostic methods and vaccines.
Journal ArticleDOI
Genome Sequence of an Unknown Subtype of Hepatitis C Virus Genotype 6: Another Piece for the Taxonomic Puzzle
Martin Schou Pedersen,Sarah Mollerup,Lone Gilmor Nielsen,Håvard Jenssen,Jens Bukh,Jens Bukh,Kristian Schønning,Kristian Schønning +7 more
TL;DR: The complete open reading frame sequence of a hepatitis C virus genotype 6 strain of an unknown subtype that was discovered during routine subtyping of patients in the clinic is presented.