J
Jens Bukh
Researcher at University of Copenhagen
Publications - 302
Citations - 22917
Jens Bukh is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 71, co-authored 270 publications receiving 21051 citations. Previous affiliations of Jens Bukh include Copenhagen University Hospital & Hvidovre Hospital.
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Journal ArticleDOI
Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events.
Eva Haastrup,Jens Bukh,Camilla Bock,Maj Vinberg,Lise Wegner Thørner,Thomas Hansen,Thomas Werge,Lars Vedel Kessing,Henrik Ullum +8 more
TL;DR: The data suggest that this genetic trend towards higher IL-18 production may increase the susceptibility to depression in response to stressful life events.
Posted ContentDOI
In vitro efficacy of Artemisinin-based treatments against SARS-CoV-2
Kerry Gilmore,Yuyong Zhou,Santseharay Ramirez,Long V. Pham,Ulrik Fahnøe,Shan Feng,Anna Offersgaard,Jakob Trimpert,Jens Bukh,Klaus Osterrieder,Klaus Osterrieder,Judith M. Gottwein,Peter H. Seeberger,Peter H. Seeberger +13 more
TL;DR: In vitro efficacy of Artemisia annua extracts as well as artemisinin, artesunate, and artemether against SARS-CoV-2 is reported.
Journal ArticleDOI
Amplification of the full-length hepatitis A virus genome by long reverse transcription-PCR and transcription of infectious RNA directly from the amplicon
TL;DR: The modified and applied the newly described technique of "long PCR" to the synthesis of a full-length DNA amplicon from the RNA of a cytopathogenic mutant of the hepatitis A virus, showing the potential of this method for providing cDNAs of viral genomes and simplifying the construction of infectious clones.
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DNA-based vaccination against hepatitis C virus (HCV): effect of expressing different forms of HCV E2 protein and use of CpG-optimized vectors in mice.
Xiaoying Ma,Xavier Forns,Robin A. Gutierrez,Isa K. Mushahwar,Tong Wu,Paul J. Payette,Jens Bukh,Robert H. Purcell,Heather L. Davis +8 more
TL;DR: It is demonstrated that membrane-bound and secreted forms induced higher titers of E2-specific antibodies, as well as earlier and higher seroconversion rates, than the intracellular form, but all three forms induced strong CTL.
Journal ArticleDOI
Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design
Zhen-Yong Keck,Brian G. Pierce,Patrick Lau,Janine Lu,Yong Wang,Alexander Underwood,Rowena A. Bull,Jannick Prentoe,Rodrigo Velázquez-Moctezuma,Melanie R. Walker,Fabio Luciani,Johnathan D. Guest,Catherine Fauvelle,Catherine Fauvelle,Thomas F. Baumert,Thomas F. Baumert,Jens Bukh,Andrew R. Lloyd,Steven K. H. Foung +18 more
TL;DR: The results define epitope determinants for antibody E2 targeting with important implications for the development of a B cell vaccine.