J
Jens Bukh
Researcher at University of Copenhagen
Publications - 302
Citations - 22917
Jens Bukh is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 71, co-authored 270 publications receiving 21051 citations. Previous affiliations of Jens Bukh include Copenhagen University Hospital & Hvidovre Hospital.
Papers
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Journal ArticleDOI
Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system
Yi-Ping Li,Santseharay Ramirez,Santseharay Ramirez,Sanne B. Jensen,Sanne B. Jensen,Robert H. Purcell,Judith M. Gottwein,Judith M. Gottwein,Jens Bukh,Jens Bukh,Jens Bukh +10 more
TL;DR: A highly efficient genotype 1a (strain TN) full-length culture system that might permit culture development for other HCV isolates, thus facilitating vaccine development and personalized treatment is developed.
Journal ArticleDOI
Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection
Tanja B. Jensen,Judith M. Gottwein,Troels K. H. Scheel,Troels K. H. Scheel,Anne Mette Hoegh,Jesper Eugen-Olsen,Jens Bukh,Jens Bukh,Jens Bukh +8 more
TL;DR: The SA13/JFH1 culture permits genotype 5a-specific studies of Core-NS2 function and interfering agents, and the ability of HCV to spread in vivo during treatment with neutralizing antibodies was confirmed in vitro.
Journal ArticleDOI
A comprehensive system for consistent numbering of HCV sequences, proteins and epitopes.
Carla Kuiken,Christophe Combet,Jens Bukh,Tadasu Shin-I,Gilbert Deléage,Masashi Mizokami,Russell Richardson,Erwin Sablon,Karina Yusim,Jean-Michel Pawlotsky,Peter Simmonds +10 more
TL;DR: A numbering system adapted from the Los Alamos HIV database with elements from the hepatitis B virus numbering system is proposed, which comprises both nucleotides and amino acid sequences and epitopes for HCV polyprotein and the untranslated regions.
Journal ArticleDOI
Cooperativity in Virus Neutralization by Human Monoclonal Antibodies to Two Adjacent Regions Located at the Amino Terminus of Hepatitis C Virus E2 Glycoprotein
Zhen-Yong Keck,Wenyan Wang,Yong Wang,Patrick Lau,Thomas H. R. Carlsen,Jannick Prentoe,Jinming Xia,Arvind H. Patel,Jens Bukh,Steven K. H. Foung +9 more
TL;DR: It is demonstrated that both of these E2 regions participate in epitopes mediating virus neutralization and that the antibodies to aa 412 to 423 and aa 434 to 446 do not hinder their respective virus-neutralizing activities.
Book ChapterDOI
Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems.
TL;DR: JFH1-based systems now enable in vitro studies of the function of viral proteins, their interaction with each other and host proteins, new antivirals, and neutralizing antibodies in the context of the full viral life cycle.