J
Jens Bukh
Researcher at University of Copenhagen
Publications - 302
Citations - 22917
Jens Bukh is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 71, co-authored 270 publications receiving 21051 citations. Previous affiliations of Jens Bukh include Copenhagen University Hospital & Hvidovre Hospital.
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Journal ArticleDOI
Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model.
TL;DR: It is indicated that RBV action on HCV in hepatoma cell-culture is exerted through increase in mutagenesis, mediated by RBV triphosphate, and leading to production of non-infectious viruses.
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Personality and the Long-Term Outcome of First-Episode Depression: A Prospective 5-Year Follow-Up Study.
TL;DR: Comorbidity of cluster C personality disorders and the level of neuroticism and extraversion have significant impact on the long-term prognosis of depression.
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Antidepressive-drug-induced bodyweight gain is associated with polymorphisms in genes coding for COMT and TPH1.
Anna Secher,Jens Bukh,Camilla Bock,Pernille Koefoed,Henrik B. Rasmussen,Thomas Werge,Lars Vedel Kessing,Erling T. Mellerup +7 more
TL;DR: Polymorphisms in catechol-O-methyltransferase, tryptophan hydroxylase (TPH1), serotonin receptor 2C (HTR2C) and serotonin transporter (SLC6A4) genes were identified and associated with bodyweight gain during treatment, when adjusted for age and sex.
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Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.
Stéphanie B. N. Serre,Sanne B. Jensen,Lubna Ghanem,Daryl Humes,Santseharay Ramirez,Yi-Ping Li,Henrik Krarup,Jens Bukh,Judith M. Gottwein +8 more
TL;DR: In a single-cycle production assay, across genotypes, PI treatment primarily decreased viral replication, which was rescued by PI resistance substitutions, which resulted in differential effects on viral fitness, depending on the original recombinant and the substitution.
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Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant
Christian K. Mathiesen,Jannick Prentoe,Luke W. Meredith,Tanja B. Jensen,Henrik Krarup,Jane A. McKeating,Judith M. Gottwein,Jens Bukh +7 more
TL;DR: This study offers important functional data on how cell culture-adaptive mutations identified in genotype 5a JFH1-based HCVcc permit high-titer culture by affecting HCV genesis through increasing virus assembly and HCV fitness by enhancing the virus specific infectivity and cell-to-cell transmission ability, without influencing the biophysical particle properties.