J
Jesse R. Dixon
Researcher at Salk Institute for Biological Studies
Publications - 55
Citations - 19302
Jesse R. Dixon is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Chromatin & Genome. The author has an hindex of 23, co-authored 45 publications receiving 15663 citations. Previous affiliations of Jesse R. Dixon include Howard Hughes Medical Institute & University of California, San Diego.
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Journal ArticleDOI
Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells.
Jessica Zuin,Jesse R. Dixon,Michael I.J.A. van der Reijden,Zhen Ye,Zhen Ye,Petros Kolovos,Rutger W W Brouwer,Mariëtte van de Corput,Harmen J.G. van de Werken,Tobias Knoch,Wilfred F. J. van IJcken,Frank Grosveld,Bing Ren,Bing Ren,Kerstin S. Wendt +14 more
TL;DR: Depletion of the cohesin complex or CTCF is depleted and the consequences of loss of these factors on higher-order chromatin organization, as well as the transcriptome, are examined, suggesting that CTCFs contribute differentially to Chromatin organization and gene regulation.
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Chromatin Domains: The Unit of Chromosome Organization
TL;DR: Recent progress in characterization of chromatin domains and delineation of mechanisms of their formation in animal cells are reviewed, providing a new molecular framework for the study of animal development and human diseases.
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Allelic reprogramming of 3D chromatin architecture during early mammalian development
Zhenhai Du,Hui Zheng,Bo Huang,Rui Ma,Jingyi Wu,Xianglin Zhang,Jing He,Yunlong Xiang,Qiujun Wang,Yuanyuan Li,Jing Ma,Xu Zhang,Ke Zhang,Yang Wang,Michael Q. Zhang,Juntao Gao,Jesse R. Dixon,Xiaowo Wang,Jianyang Zeng,Wei Xie +19 more
TL;DR: The data suggest that chromatin may exist in a markedly relaxed state after fertilization, followed by progressive maturation of higher-order chromatin architecture during early development, as characterized by slow consolidation of TADs and segregation of chromatin compartments in preimplantation development.
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Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing.
TL;DR: HaploSeq is demonstrated, an approach for assembling chromosome-scale haplotypes by exploiting the existence of 'chromosome territories', and methods based on proximity ligation and sequencing lend support for their use as a general tool for haplotyping.
Journal ArticleDOI
Integrative detection and analysis of structural variation in cancer genomes
Jesse R. Dixon,Jie Xu,Vishnu Dileep,Ye Zhan,Fan Song,Victoria T. Le,Galip Gürkan Yardımcı,Abhijit Chakraborty,Darrin V. Bann,Yanli Wang,Royden A. Clark,Lijun Zhang,Hongbo Yang,Tingting Liu,Sriranga Iyyanki,Lin An,Christopher Pool,Takayo Sasaki,Juan Carlos Rivera-Mulia,Hakan Ozadam,Bryan R. Lajoie,Rajinder Kaul,Michael Buckley,Kristen Lee,Morgan Diegel,Dubravka Pezic,Christina Ernst,Suzana Hadjur,Duncan T. Odom,Duncan T. Odom,John A. Stamatoyannopoulos,James R. Broach,Ross C. Hardison,Ferhat Ay,Ferhat Ay,William Stafford Noble,Job Dekker,Job Dekker,David M. Gilbert,Feng Yue +39 more
TL;DR: An integrative framework for identifying structural variants (SVs) in cancer that applies optical mapping, Hi-C, and whole-genome sequencing is presented and finds SVs affecting distal regulatory sequences, DNA replication, and three-dimensional chromatin structure.