Jesse R. Dixon

TL;DR: This study identifies potential novel therapeutic vulnerabilities in ependymoma and extends the ability to reveal tumor-dependency genes and pathways by oncogenic 3D genome conformations even in tumors that lack known genetic alterations.

TL;DR: Zhang et al. as discussed by the authors developed a new probabilistic model, named phylogenetic hidden Markov random field (Phylo-HMRF), to identify evolutionary patterns of 3D genome structures based on multi-species Hi-C data by jointly utilizing spatial constraints among genomic loci and continuous-trait evolutionary models.

TL;DR: In this article , the authors comprehensively mapped 3D chromatin organization during Treg cell differentiation, and showed that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression.

TL;DR: The findings of the proof-of-principle study that investigated the evolutionary history of complex rearrangements in primary head and neck tumor genomes integrating long-read whole-genome, Hi-C, and RNA sequencing highlight the need for multi-modal sequencing strategies to increase the understanding of cancer evolution and rare biomarkers in poorly understood cancers.