J
Jiajie Wei
Researcher at National Institutes of Health
Publications - 26
Citations - 566
Jiajie Wei is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & T cell. The author has an hindex of 13, co-authored 23 publications receiving 410 citations. Previous affiliations of Jiajie Wei include Texas A&M University & Shandong University.
Papers
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Journal ArticleDOI
Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.
Jiajie Wei,Rigel J. Kishton,Matthew Angel,Crystal S. Conn,Nicole Dalla-Venezia,Virginie Marcel,Anne Vincent,Frédéric Catez,Sabrina Ferré,Lilia Ayadi,Virginie Marchand,Devin Dersh,James Gibbs,Ivaylo Ivanov,Nathan Fridlyand,Yohann Couté,Jean-Jacques Diaz,Shu-Bing Qian,Louis M. Staudt,Nicholas P. Restifo,Jonathan W. Yewdell +20 more
TL;DR: It is shown that 60S ribosomal proteins L6 and RPL28, which are adjacent on the ribosome, play opposite roles in generating an influenza A virus-encoded peptide, which raises the possibility of modulating immunosurveillance by pharmaceutical targeting ribosomes.
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Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility
TL;DR: It is shown that incomplete IAV particles lacking gene segments contribute to the propagation of the viral population through multiplicity reactivation under conditions of widespread coinfection, which it is demonstrated commonly occurs in the upper respiratory tract of guinea pigs.
Journal ArticleDOI
The arginine attenuator peptide interferes with the ribosome peptidyl transferase center.
TL;DR: The data indicate that inhibition of PTC function by the AAP in response to Arg is the basis for the AAP's function of stalling ribosomes at the uORF termination codon.
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Generation of SARS-CoV-2 reporter replicon for high-throughput antiviral screening and testing.
Xi He,Shuo Quan,Min Xu,Silveria Rodriguez,Shih Lin Goh,Jiajie Wei,Arthur Fridman,Kenneth A. Koeplinger,Steve S. Carroll,Jay A. Grobler,Amy S. Espeseth,David B. Olsen,Daria J. Hazuda,Dai Wang +13 more
TL;DR: In this article, the authors presented a noninfectious SARS-CoV-2 reporter replicon and its application in deciphering viral replication mechanisms and evaluating SARS CoV2 inhibitors.
Journal ArticleDOI
Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature.
J Morel,J Morel,Anja O. Paatero,Jiajie Wei,Jonathan W. Yewdell,Laure Guenin-Macé,Laure Guenin-Macé,Delphi Van Haver,Francis Impens,Natalia Pietrosemoli,Ville O. Paavilainen,Caroline Demangel,Caroline Demangel +12 more
TL;DR: Quantitative proteomics reveals that Sec61 blockade induces proteostatic stress in the cytosol and the endoplasmic reticulum, refining the mechanistic understanding of Sec61 inhibition by mycolactone.