Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.
Jiajie Wei,Rigel J. Kishton,Matthew Angel,Crystal S. Conn,Nicole Dalla-Venezia,Virginie Marcel,Anne Vincent,Frédéric Catez,Sabrina Ferré,Lilia Ayadi,Virginie Marchand,Devin Dersh,James Gibbs,Ivaylo Ivanov,Nathan Fridlyand,Yohann Couté,Jean-Jacques Diaz,Shu-Bing Qian,Louis M. Staudt,Nicholas P. Restifo,Jonathan W. Yewdell +20 more
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TLDR
It is shown that 60S ribosomal proteins L6 and RPL28, which are adjacent on the ribosome, play opposite roles in generating an influenza A virus-encoded peptide, which raises the possibility of modulating immunosurveillance by pharmaceutical targeting ribosomes.About:
This article is published in Molecular Cell.The article was published on 2019-03-21 and is currently open access. It has received 68 citations till now. The article focuses on the topics: Ribosomal protein & Immunosurveillance.read more
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A few good peptides: MHC class I-based cancer immunosurveillance and immunoevasion.
TL;DR: How dysregulated protein translation in cancer cells is an important source of tumour-specific peptides for immunosurveillance and how MHC class I antigen-processing and presentation pathways are manipulated by tumours for immunoevasion are described — information that will inform cancer immunotherapy approaches.
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Most non-canonical proteins uniquely populate the proteome or immunopeptidome.
Maria Virginia Ruiz Cuevas,Marie-Pierre Hardy,Jaroslav Hollý,Eric Bonneil,Chantal Durette,Mathieu Courcelles,Joel Lanoix,Caroline Côté,Louis M. Staudt,Sébastien Lemieux,Pierre Thibault,Claude Perreault,Jonathan W. Yewdell +12 more
TL;DR: In this paper, the contribution of non-canonical translation to the proteome and major histocompatibility complex (MHC) class I immunopeptidome was investigated.
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Identification of the Cryptic HLA-I Immunopeptidome
TL;DR: Peptide-PRISM represents an important step toward comprehensive identification of HLA-I immunopeptidomes and reveals cryptic peptides as an abundant class of epitopes with potential relevance for novel immunotherapeutic approaches.
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Beneficial autoimmunity improves cancer prognosis.
TL;DR: In this article, the authors discuss examples of spontaneous as well as therapy-induced auto-immunity that correlate with favorable disease outcomes and make a strong case in favour of this "beneficial auto immunity" being important not only in patients with advanced-stage disease but also in cancer immunosurveillance.
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The Ubiquitin-Proteasome System in Immune Cells.
TL;DR: The ubiquitin-proteasome system (UPS) is the major intracellular and non-lysosomal protein degradation system as mentioned in this paper, which is responsible for eliminating old, damaged, misfolded, and regulatory proteins in a highly specific manner.
References
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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.
Jiirgen Cox,Matthias Mann +1 more
TL;DR: MaxQuant, an integrated suite of algorithms specifically developed for high-resolution, quantitative MS data, detects peaks, isotope clusters and stable amino acid isotope–labeled (SILAC) peptide pairs as three-dimensional objects in m/z, elution time and signal intensity space and achieves mass accuracy in the p.p.b. range.
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