Jian Luo

TL;DR: It is reported that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also called GPR48) is another receptor for RANKL that negatively regulates osteoclast differentiation and bone resorption.

TL;DR: GA significantly inhibited human umbilical vascular endothelial cell (HUVEC) proliferation, migration, invasion, tube formation, and microvessel growth at nanomolar concentration and was more effective in activating apoptosis and inhibiting proliferation and migration in HUVECs than in human prostate cancer cells (PC3), suggesting GA might be a potential drug candidate in cancer therapy through angioprevention with low chemotoxicity.

TL;DR: Gpr48 regulates bone formation and remodeling through the cAMP-PKA-Atf4 signaling pathway and significantly downregulates the expression levels of Atf4 target genes/proteins, such as osteocalcin, bone sialoprotein and collagen.

TL;DR: The mussel-inspired nanostructures in 3D-printed bioceramic exhibited a remarkable capability for both cancer therapy and bone regeneration, offering a promising strategy to construct bifunctional biomaterials which could be widely used for therapy of tumor-induced tissue defects.

TL;DR: This review focuses on the signaling transduction pathways of the adhesion GPCR family, the LGR sub family, and the PSGR subfamily, and their potential functions in immunology, development, and cancers.