J
Jian Luo
Researcher at East China Normal University
Publications - 67
Citations - 3533
Jian Luo is an academic researcher from East China Normal University. The author has contributed to research in topics: Osteoclast & Metastasis. The author has an hindex of 31, co-authored 67 publications receiving 2952 citations. Previous affiliations of Jian Luo include Second Military Medical University & Hunan Normal University.
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Journal ArticleDOI
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.
Jian Luo,Zhengfeng Yang,Yu Ma,Zhiying Yue,Hongyu Lin,Guojun Qu,Jinping Huang,Wentao Dai,Chenghai Li,Chunbing Zheng,Leqin Xu,Huaqing Chen,Jiqiu Wang,Dali Li,Stefan Siwko,Josef M. Penninger,Guang Ning,Jianru Xiao,Jianru Xiao,Mingyao Liu,Mingyao Liu +20 more
TL;DR: It is reported that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also called GPR48) is another receptor for RANKL that negatively regulates osteoclast differentiation and bone resorption.
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Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling.
Tingfang Yi,Zhengfang Yi,Sung Gook Cho,Jian Luo,Manoj K. Pandey,Bharat B. Aggarwal,Mingyao Liu,Mingyao Liu +7 more
TL;DR: GA significantly inhibited human umbilical vascular endothelial cell (HUVEC) proliferation, migration, invasion, tube formation, and microvessel growth at nanomolar concentration and was more effective in activating apoptosis and inhibiting proliferation and migration in HUVECs than in human prostate cancer cells (PC3), suggesting GA might be a potential drug candidate in cancer therapy through angioprevention with low chemotoxicity.
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Regulation of bone formation and remodeling by G-protein-coupled receptor 48
Jian Luo,Jian Luo,Jian Luo,Wei Zhou,Xin Zhou,Dali Li,Dali Li,Jinsheng Weng,Zhengfang Yi,Sung Gook Cho,Chenghai Li,Tingfang Yi,Xiushan Wu,Xiaoying Li,Benoit de Crombrugghe,Magnus Höök,Mingyao Liu,Mingyao Liu +17 more
TL;DR: Gpr48 regulates bone formation and remodeling through the cAMP-PKA-Atf4 signaling pathway and significantly downregulates the expression levels of Atf4 target genes/proteins, such as osteocalcin, bone sialoprotein and collagen.
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3D printing of biomaterials with mussel-inspired nanostructures for tumor therapy and tissue regeneration.
TL;DR: The mussel-inspired nanostructures in 3D-printed bioceramic exhibited a remarkable capability for both cancer therapy and bone regeneration, offering a promising strategy to construct bifunctional biomaterials which could be widely used for therapy of tumor-induced tissue defects.
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Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets
TL;DR: This review focuses on the signaling transduction pathways of the adhesion GPCR family, the LGR sub family, and the PSGR subfamily, and their potential functions in immunology, development, and cancers.