M
Massimo Cardinali
Researcher at National Institutes of Health
Publications - 12
Citations - 843
Massimo Cardinali is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA vaccination & Immunogenicity. The author has an hindex of 12, co-authored 12 publications receiving 817 citations.
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Journal ArticleDOI
Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery
Spyros A. Kalams,Scott D. Parker,Marnie Elizaga,Barbara Metch,Srilatha Edupuganti,John Hural,Stephen C. De Rosa,Donald K. Carter,Kyle Rybczyk,Ian Frank,Jonathan D. Fuchs,Beryl A. Koblin,Denny H. Kim,Patrice Joseph,Michael C. Keefer,Lindsey R. Baden,John H. Eldridge,Jean D. Boyer,Adam Sherwat,Massimo Cardinali,Mary Allen,Michael Pensiero,Christopher C Butler,Amir S. Khan,Jian Yan,Niranjan Y. Sardesai,James G. Kublin,David B. Weiner +27 more
TL;DR: This study illustrates the power of combined DNA approaches to generate impressive immune responses in humans by using electroporation after PV administration to provide immunogenicity superior to that observed in the trial without Electroporation, despite fewer vaccinations.
Journal ArticleDOI
Phase 1 Safety and Immunogenicity Testing of DNA and Recombinant Modified Vaccinia Ankara Vaccines Expressing HIV-1 Virus-like Particles
Paul A. Goepfert,Marnie Elizaga,Alicia Sato,Li Qin,Massimo Cardinali,Christine M. Hay,John Hural,Stephen C. DeRosa,Olivier D. Defawe,Georgia D. Tomaras,David C. Montefiori,Yongxian Xu,Lilin Lai,Spyros A. Kalams,Lindsey R. Baden,Sharon E. Frey,William A. Blattner,Linda S. Wyatt,Bernard Moss,Harriet L. Robinson +19 more
TL;DR: MVA62 was well tolerated and elicited different patterns of T cell and Ab responses when administered alone or in combination with the JS7 DNA vaccine.
Journal ArticleDOI
Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies.
TL;DR: Functional evidence that growth pathways are aberrantly regulated in cell lines representing SCC of the upper aerodigestive tract is provided.
Journal ArticleDOI
Safety and immunogenicity of an HIV-1 gag DNA vaccine with or without IL-12 and/or IL-15 plasmid cytokine adjuvant in healthy, HIV-1 uninfected adults.
Spyros A. Kalams,Scott D. Parker,Xia Jin,Marnie Elizaga,Barbara Metch,Maggie Wang,John Hural,Michael David Lubeck,John H. Eldridge,Massimo Cardinali,William A. Blattner,Magda Sobieszczyk,Vinai Suriyanon,Artur Kalichman,David B. Weiner,Lindsey R. Baden +15 more
TL;DR: There were minimal responses to HIV gag DNA alone, and no apparent augmentation with either IL-12 or IL-15 plasmid cytokine adjuvants, despite the promise of DNA vaccines, newer formulations or methods of delivery will be required to increase their immunogenicity.
Journal ArticleDOI
A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects
Michael C. Keefer,Sharon E. Frey,Marnie Elizaga,Barbara Metch,Stephen C. De Rosa,Paulo Feijó Barroso,Georgia D. Tomaras,Massimo Cardinali,Paul A. Goepfert,Artur Kalichman,Valerie Philippon,M. Juliana McElrath,Xia Jin,Guido Ferrari,Olivier D. Defawe,Gail P. Mazzara,David C. Montefiori,Michael Pensiero,Dennis Panicali,Lawrence Corey +19 more
TL;DR: A heterologous poxvirus vector prime-boost regimen can induce HIV-specific CD8+ T-cell and CD4-cell responses, which may be an important feature of an optimal regimen for preventive HIV vaccination.