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Open AccessJournal ArticleDOI

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc- Activity.

Xinxin Song, +16 more
- 06 Aug 2018 - 
- Vol. 28, Iss: 15, pp 2388
TLDR
It is shown that BECN1 plays a hitherto unsuspected role in promoting ferroptosis through directly blocking system Xc- activity via binding to its core component, SLC7A11 (solute carrier family 7 member 11).
About: 
This article is published in Current Biology.The article was published on 2018-08-06 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Necroptosis & AMPK.

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Citations
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Biological Functions of Autophagy Genes: A Disease Perspective

Beth Levine, +1 more
- 10 Jan 2019 - 
TL;DR: The biological functions of autophagy genes are discussed from the perspective of understanding-and potentially reversing-the pathophysiology of human disease and aging.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

The molecular machinery of regulated cell death

Daolin Tang, +5 more
- 04 Apr 2019 - 
TL;DR: The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.
Journal ArticleDOI

Ferroptosis: molecular mechanisms and health implications

Daolin Tang, +4 more
- 01 Feb 2021 - 
TL;DR: How dysregulated ferroptosis is involved in cancer, neurodegeneration, tissue injury, inflammation, and infection is described.
Journal ArticleDOI

Broadening horizons: the role of ferroptosis in cancer.

Xin Chen, +5 more
- 29 Jan 2021 - 
TL;DR: In this paper, the key molecular mechanisms of ferroptosis, including crosstalk with tumour-associated signalling pathways, and discuss potential therapeutic applications of the process are presented.
References
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Journal ArticleDOI

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, +12 more
- 25 May 2012 - 
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
Journal ArticleDOI

Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal.

Antonio Ayala, +2 more
- 08 May 2014 - 
TL;DR: This review focuses on biochemical concepts of lipidPeroxidation, production, metabolism, and signaling mechanisms of two main omega-6 fatty acids lipid peroxidation products: malondialdehyde (MDA) and, in particular, 4-hydroxy-2-nonenal (4-HNE), summarizing not only its physiological and protective function as signaling molecule stimulating gene expression and cell survival, but also its cytotoxic role inhibiting geneexpression and promoting cell death.
Journal ArticleDOI

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang, +15 more
- 16 Jan 2014 - 
TL;DR: Targeted metabolomic profiling and chemoproteomics revealed that GPX4 is an essential regulator of ferroptotic cancer cell death and sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPx4-regulated ferroPTosis.
Journal ArticleDOI

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.

Sophie Pattingre, +11 more
- 23 Sep 2005 - 
TL;DR: Bcl-2 not only functions as an antiapoptotic protein, but also as an antiautophagy protein via its inhibitory interaction with Beclin 1, which may help maintain autophagy at levels that are compatible with cell survival, rather than cell death.
Journal ArticleDOI

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell, +27 more
- 05 Oct 2017 - 
TL;DR: The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended.
Related Papers (5)

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, +12 more
- 25 May 2012 - 

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang, +15 more
- 16 Jan 2014 - 

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell, +27 more
- 05 Oct 2017 - 

Ferroptosis: process and function.

Yangchun Xie, +8 more
- 01 Mar 2016 - 

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

José Pedro Friedmann Angeli, +28 more
- 01 Dec 2014 -