Jiaxing Chen

TL;DR: In this paper, the authors review what computer, in vitro, in vivo, and pharmacological experiments tell us about the accumulation and deposition of the oligomers of the (Aβ, tau), α-synuclein, IAPP, and superoxide dismutase 1 proteins, which have been the mainstream concept underlying Alzheimer's disease, Parkinson's disease (PD), type II diabetes (T2D), and amyotrophic lateral sclerosis (ALS) research.

TL;DR: In this article, the authors used inter-dye distance distributions from bulk time-resolved Forster resonance energy transfer as restraints in discrete molecular dynamics simulations to map the conformational space of the α-synuclein monomer.

TL;DR: In this article, the concept of allostery in proteins and various approaches to identify allosteric sites and pathways are reviewed and an overview of strategies and tools used in protein regulation and their utility in biological applications is provided.

TL;DR: A review of the most recent and state-of-the-art techniques for allosteric communication engineering can be found in this article , where the authors highlight the challenges that need to be overcome and future directions for engineering protein allostery.

TL;DR: In this paper, an engineered, single protein design that is allosterically regulated to function as a "two-input logic OR gate" was presented, based on chemo-and optogenetic regulation of focal adhesion kinase.