John E. Straub

TL;DR: The results demonstrate that use of ab initio structural and energetic data by themselves are not sufficient to obtain an adequate backbone representation for peptides and proteins in solution and in crystals.

TL;DR: In this article, the determination des constantes de vitesses dans les gaz and les liquides is discussed. And the methodes theoriques and techniques numeriques for des systemes isoles ou dans des solvants are presented.

TL;DR: The dock–lock mechanism should be a generic mechanism for growth of oligomers of amyloidogenic peptides, and surprisingly, the mobile structured oligomers undergo large conformational changes in order to accommodate the added monomer.

TL;DR: Evidence is offered that a two-step model, similar to that postulated for protein crystallization, must also hold for higher order amyloid structure formation starting from N*.

TL;DR: In this paper, the authors review what computer, in vitro, in vivo, and pharmacological experiments tell us about the accumulation and deposition of the oligomers of the (Aβ, tau), α-synuclein, IAPP, and superoxide dismutase 1 proteins, which have been the mainstream concept underlying Alzheimer's disease, Parkinson's disease (PD), type II diabetes (T2D), and amyotrophic lateral sclerosis (ALS) research.