Brianna Hnath

TL;DR: In this paper, the authors review what computer, in vitro, in vivo, and pharmacological experiments tell us about the accumulation and deposition of the oligomers of the (Aβ, tau), α-synuclein, IAPP, and superoxide dismutase 1 proteins, which have been the mainstream concept underlying Alzheimer's disease, Parkinson's disease (PD), type II diabetes (T2D), and amyotrophic lateral sclerosis (ALS) research.

TL;DR: This study designed candidate stable immunogens that mimic surface features of selected conserved regions of spike protein through ‘epitope grafting,’ in which the target epitope topology is presented on diverse heterologous scaffolds that can structurally accommodate the spike epitopes.

TL;DR: In this paper , the authors used epitope grafting to construct scaffolds for SARS-CoV-2 epitope vaccine design and demonstrated the potential utility of grafting in rational vaccine design.

TL;DR: In this article , the toxic SOD1 trimer is shown to be an off-pathway intermediate competing with protective fibril formation, which is a critical determinant of potential therapeutic approaches to treat ALS.

TL;DR: In this paper , the role of different size aggregates in disease, and how factors contributing to aggregation may promote oligomers opposed to fibrils, are reviewed and two different computational modeling strategies (molecular dynamics and kinetic modeling) and how they are used to model both oligomers and Fibrils.