Bodu Liu

TL;DR: This work identifies an NF-KappaB Interacting LncRNA (NKILA), which is upregulated by NF-κB, binds to NF-σκB/IκBs, and directly masks phosphorylation motifs of IKKB, thereby inhibiting IKK-induced IκBosphorylation and NF-kkB activation.

TL;DR: In this article, the authors show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival.

TL;DR: It is demonstrated that miR-21 expression was up-regulated and its function was elevated in HER2+ BT474, SKBR3, and MDA-MB-453 breast cancer cells that are induced to acquire trastuzumab resistance by long-term exposure to the antibody, whereas protein expression of the PTEN gene, a miR -21 target, was reduced.

TL;DR: Stable chemotherapy-resistant tongue squamous cell carcinoma cell lines are established by exposing the parental CAL27 and SCC25 lines to escalating concentrations of cisplatin for 6 months and it is suggested that reduced expression of miR-200b and miB-15b underscores the mechanisms of chemotherapy-induced EMT in TSCC, and may serve as therapeutic targets to reverse chemotherapy resistance in tongue cancers.

TL;DR: The present study reviews the studies and examines the roles of miRNAs in cancer diagnosis, prognosis and treatment, and discusses the potential therapeutic modality of exploiting mi RNAs.