J
Jihwan Park
Researcher at University of Pennsylvania
Publications - 53
Citations - 3736
Jihwan Park is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 23, co-authored 45 publications receiving 2125 citations. Previous affiliations of Jihwan Park include Gwangju Institute of Science and Technology & Pohang University of Science and Technology.
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Journal ArticleDOI
Gene Silencing in HIV-1 Latency by Polycomb Repressive Group
Hyeon Guk Kim,Kyung Chang Kim,Tae-Young Roh,Jihwan Park,Kyung Min Jung,Joo Shil Lee,Sang Yun Choi,Sung Soon Kim,Byeong Sun Choi +8 more
TL;DR: The results suggest that tri-methylation of histone H3K27 and H2A ubiquitylation via polycomb group protein may play a crucial role in epigenetic silencing accounting for HIV-1 latency in NCHA cells.
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Genome-wide analysis of histone modifications in latently HIV-1 infected T cells.
TL;DR: In this article, a systematic epigenome profiling could be applicable to develop new epigenetic diagnostic markers for detecting HIV-1 latency, which is a major hurdle on the pathway to HIV elimination.
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Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity.
Xiangchen Gu,Xiangchen Gu,Hongliu Yang,Hongliu Yang,Xin Sheng,Yi-An Ko,Chengxiang Qiu,Jihwan Park,Shizheng Huang,Rachel L. Kember,Renae Judy,Joseph Park,Scott M. Damrauer,Scott M. Damrauer,Girish N. Nadkarni,Ruth J. F. Loos,Vy Thi Ha My,Kumardeep Chaudhary,Erwin P. Bottinger,Ishan Paranjpe,Aparna Saha,Christopher D. Brown,Shreeram Akilesh,Adriana M. Hung,Adriana M. Hung,Matthew Palmer,Aris Baras,John D. Overton,Jeffrey S. Reid,Marylyn D. Ritchie,Daniel J. Rader,Katalin Susztak +31 more
TL;DR: In this article, the authors performed integration of kidney function GWAS and human kidney-specific expression quantitative trait analysis and identified that the expression of beta-mannosidase (MANBA) was lower in kidney of subjects with CKD risk genotype.
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Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1.
Ganeshkumar Rajendran,Michael Schonfeld,Ratnakar Tiwari,Shengping Huang,Rafael Torosyan,Timothy A. Fields,Jihwan Park,Katalin Susztak,Pinelopi P. Kapitsinou +8 more
TL;DR: Investigating the function of the endothelial PHD2/HIF axis in ischemic AKI found that endothelial Phd2 ablation protected against renal ischemia-reperfusion injury by suppressing the expression of proinflammatory genes and recruitment of inflammatory cells in a manner that was dependent on HIF-1 but not HIF2.
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Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis
Tomohito Doke,Amin Abedini,Daniel Aldridge,Ya-Wen Yang,Jihwan Park,Christina M. Hernandez,Michael S. Balzer,Rojesh Shrestra,Gaia M. Coppock,J.M. Rico,Seung Yub Han,Junhyong Kim,Sheng Xin,Adrian M. Piliponsky,Marco Angelozzi,Véronique Lefebvre,Mark C. Siracusa,Christopher A. Hunter,Katalin Susztak +18 more
TL;DR: Human kidney single-cell, bulk gene expression and immunostaining validate a function for basophils in patients with kidney fibrosis and suggest that targeting these cells might be a useful clinical strategy to manage chronic kidney disease.