Jihwan Park

TL;DR: In this article , a review on the application of scRNA-seq in investigation of the tumour immune microenvironment (TIME) is presented, and the authors concluded novel cell clusters of cancer-associated fibroblasts (CAFs), T cells, tumour-associated macrophages (TAMs) and dendritic cells (DCs) were discovered after scRNAseq in time.

TL;DR: A comprehensive single cell atlas of the kidney reveals a transitional cell type and cell plasticity determined by Notch signaling which is defective in chronic kidney disease.

TL;DR: Examination of the epigenetic modifications and the transcriptome of two types of iPSC and of partially reprogrammed iPSCs generated independently from adult cardiac and skin fibroblasts indicate that the cellular responsiveness to external stimuli should be pre-determined and sequentially orchestrated through the tight modulation of the chromatin environment during cell reprograming to prevent unexpected reprogramming.

TL;DR: IL-2-related immunological functions in latently HIV-1-infected T cells were markedly impaired even in the presence of stimuli.

TL;DR: When applied to pancreatic islet and whole kidney expression data in human, mouse, and rats, MuSiC outperformed existing methods, especially for tissues with closely related cell types.