J
Jihwan Park
Researcher at University of Pennsylvania
Publications - 53
Citations - 3736
Jihwan Park is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 23, co-authored 45 publications receiving 2125 citations. Previous affiliations of Jihwan Park include Gwangju Institute of Science and Technology & Pohang University of Science and Technology.
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Journal ArticleDOI
Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer
Tushar D. Bhagat,Yiyu Zou,Shizheng Huang,Jihwan Park,Matthew Palmer,Caroline Hu,Weijuan Li,Niraj Shenoy,Orsolya Giricz,Gaurav Choudhary,Yiting Yu,Yi-An Ko,María Concepción Izquierdo,Ae Seo Deok Park,Nishanth Vallumsetla,Remi Laurence,Robert Lopez,Masako Suzuki,James Pullman,Justin D. Kaner,Benjamin A. Gartrell,A. Ari Hakimi,John M. Greally,Bharvin K. R. Patel,Karim A. Benhadji,Kith Pradhan,Amit Verma,Katalin Susztak +27 more
TL;DR: The mechanistic basis of NOTCH pathway activation in CCRCC is revealed and this pathway to a potential therapeutic target is demonstrated.
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Increasing the level of peroxisome proliferator-activated receptor γ coactivator-1α in podocytes results in collapsing glomerulopathy.
Szu Yuan Li,Jihwan Park,Chengxiang Qiu,Seung Hyeok Han,Matthew Palmer,Zoltan Arany,Katalin Susztak +6 more
TL;DR: In this paper, peroxisome proliferator-activated receptor γ coactivator-1α (PGC1α) is one of the main transcriptional regulators of mitochondrial biogenesis and function.
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Functional elements demarcated by histone modifications in breast cancer cells.
TL;DR: Data reflects that comprehensive analysis of histone modification profiles under cell type-specific chromatin environment should provide a better chance for defining functional regulatory elements in the genome.
Journal ArticleDOI
Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting.
Orsolya Symmons,Marcello Chang,Ian A. Mellis,Jennifer M. Kalish,Jihwan Park,Katalin Susztak,Marisa S. Bartolomei,Arjun Raj +7 more
TL;DR: In this article, a single molecule allele-specific RNA FISH adapted for use on tissue sections, allowing us to determine the chromosome of origin of individual RNA molecules in formaldehyde-fixed tissues.
Journal ArticleDOI
DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development
Szu-Yuan Li,Jihwan Park,Yuting Guan,Kiwung Chung,Rojesh Shrestha,Matthew B. Palmer,Katalin Susztak +6 more
TL;DR: Genome-wide cytosine methylation and gene expression profiling showed that by silencing embryonic, nonrenal lineage genes and transposable elements, DNMT1-mediated cytosin methylation is essential for kidney development.