J
Jihwan Park
Researcher at University of Pennsylvania
Publications - 53
Citations - 3736
Jihwan Park is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 23, co-authored 45 publications receiving 2125 citations. Previous affiliations of Jihwan Park include Gwangju Institute of Science and Technology & Pohang University of Science and Technology.
Papers
More filters
Posted ContentDOI
Jagged1/Notch2 Controls Kidney Fibrosis via Tfam-mediated Metabolic Reprogramming
Shizheng Huang,Jihwan Park,Chengxiang Qiu,Yasemin Sirin,Seung Hyeok Han,Szu Yuan Li,Verdon Taylor,Ursula Zimber-Strobl,Katalin Susztak +8 more
TL;DR: JAG1 and NOTCH2 showed the strongest correlation with the degree of interstitial fibrosis in a genome wide expression analysis of a large cohort of human kidney samples and played a key role in kidney fibrosis development by regulating Tfam expression and metabolic reprogramming.
Journal ArticleDOI
Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses.
Gaia M. Coppock,Lillian R. Aronson,Jihwan Park,Chengxiang Qiu,Jeongho Park,Jonathan H. DeLong,Enrico Radaelli,Katalin Susztak,Christopher A. Hunter +8 more
TL;DR: Ex vivo data suggest that endogenous IL-27 acts at several points in the inflammatory cascade to limit the magnitude of immune-mediated damage to the kidney.
Journal ArticleDOI
Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidney Disease.
TL;DR: Whole-genome bisulfite sequencing indicated that DnMT3a and Dnmt3b play an important role in methylation of gene regulatory regions that act as fetal-specific enhancers in the developing kidney but are decommissioned in the mature kidney.
Posted ContentDOI
Genome-wide association study of diabetic kidney disease highlights biology involved in renal basement membrane collagen
Rany M. Salem,Jennifer N. Todd,Jennifer N. Todd,Jennifer N. Todd,Niina Sandholm,Joanne B. Cole,Joanne B. Cole,Joanne B. Cole,Wei-Min Chen,Darrel Andrews,Marcus G. Pezzolesi,Paul M. McKeigue,Linda T Hiraki,Chengxiang Qiu,Viji Nair,Chen Di Liao,Jing Jing Cao,Erkka Valo,Suna Onengut-Gumuscu,Adam M. Smiles,Stuart J. McGurnaghan,Jani K. Haukka,Valma Harjutsalo,Eoin P. Brennan,Natalie R. van Zuydam,Natalie R. van Zuydam,Emma Ahlqvist,Ross Doyle,Tarunveer S. Ahluwalia,Maria Lajer,Maria Hughes,Jihwan Park,Jan Skupien,Athina Spiliopoulou,Andrew S.K. Liu,Rajasree Menon,Carine M. Boustany-Kari,Hyun Min Kang,Robert G. Nelson,Ronald Klein,Barbara E.K. Klein,Kristine E. Lee,Xiaoyu Gao,Michael Mauer,Silvia Maeastroni,Maria Luiza Caramori,Ian H. de Boer,Rachel G. Miller,Jingchuan Guo,Andrew P. Boright,David-Alexandre Trégouët,David-Alexandre Trégouët,Beata Gyorgy,Beata Gyorgy,Janet K. Snell-Bergeon,David M. Maahs,Shelley B. Bull,Angelo J. Canty,Colin N. A. Palmer,Lars Stechemesser,Bernhard Paulweber,Raimund Weitgasser,Jelizaveta Sokolovska,Vita Rovīte,Valdis Pīrāgs,Edita Prakapiene,Lina Radzeviciene,Rasa Verkauskiene,Nicolae Mircea Panduru,Nicolae Mircea Panduru,Leif Groop,Leif Groop,Mark I. McCarthy,Mark I. McCarthy,Harvest F. Gu,Harvest F. Gu,Anna Möllsten,Henrik Falhammar,Henrik Falhammar,Kerstin Brismar,Kerstin Brismar,Dcct,F Martin,F Martin,Peter Rossing,Tina Costacou,Gianpaolo Zerbini,Gianpaolo Zerbini,Michel Marre,Michel Marre,Samy Hadjadj,Amy J. McKnight,Carol Forsblom,Gareth J. McKay,Catherine Godson,A. Peter Maxwell,Matthias Kretzler,Katalin Susztak,Helen M. Colhoun,Andrzej Krolewski,Andrew D. Paterson,Per-Henrik Groop,Stephen S. Rich,Stephen S. Rich,Joel N. Hirschhorn,Jose C. Florez +105 more
TL;DR: The 16 DKD-associated loci provide novel insights into the pathogenesis of DKD, identifying potential biological targets for prevention and treatment.
Journal ArticleDOI
The effect of CD4 receptor downregulation and its downstream signaling molecules on HIV-1 latency
Kyung Chang Kim,Hyeon Guk Kim,Tae-Young Roh,Jihwan Park,Kyung Min Jung,Joo Shil Lee,Sang Yun Choi,Sung Soon Kim,Byeong Sun Choi +8 more
TL;DR: It is demonstrated that the HIV-1 latent state is sustained by the reduction of downstream signaling molecules via the downregulation of CD4 and the attenuated activity of transcription factor as AP-1.