J
Jin-Sung Park
Researcher at Seoul National University Hospital
Publications - 60
Citations - 1922
Jin-Sung Park is an academic researcher from Seoul National University Hospital. The author has contributed to research in topics: Medicine & Acute toxicity. The author has an hindex of 16, co-authored 45 publications receiving 1492 citations. Previous affiliations of Jin-Sung Park include Kolling Institute of Medical Research & RIKEN Brain Science Institute.
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Journal ArticleDOI
Mitochondrial Dysfunction in Parkinson's Disease: New Mechanistic Insights and Therapeutic Perspectives.
TL;DR: Increasing evidence supports the critical role for mitochondrial dysfunction in the development of sporadic PD, while the involvement of familial PD-related genes in the regulation of mitochondrial biology has been expanded by the discovery of new mitochondria-associated disease loci and the identification of their novel functions.
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Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes
Stephanie M.Y. Kong,Brian K.K. Chan,Jin-Sung Park,Kathryn J. Hill,Jade B. Aitken,Jade B. Aitken,Jade B. Aitken,Louise Cottle,Hovik Farghaian,Adam R. Cole,Peter A. Lay,Carolyn M. Sue,Antony A. Cooper,Antony A. Cooper +13 more
TL;DR: It is proposed ATP13A2's modulation of zinc levels in MVBs can regulate the biogenesis of exosomes capable of containing α-Synuclein, the first PD-associated gene involved in exosome biogenesis and indicates a potential neuroprotective role ofExosomes in PD.
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A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism
Keiichi Inoue,Keiichi Inoue,Keiichi Inoue,Yuko Mikuni-Takagaki,Kaoru Oikawa,Takeshi Itoh,Masaki Inada,Takanori Noguchi,Jin-Sung Park,Jin-Sung Park,Takashi Onodera,Stephen M. Krane,Masaki Noda,Shigeyoshi Itohara +13 more
TL;DR: It is proposed that osteocytic network formation is a determinant of bone remodeling and mineralization and that MMP-2 plays a crucial role in forming and maintaining the osteocytics canalicular network.
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Whispering dysphonia (DYT4 dystonia) is caused by a mutation in the TUBB4 gene
Katja Lohmann,Robert A. Wilcox,Susen Winkler,Alfredo Ramirez,Alfredo Ramirez,Aleksandar Rakovic,Jin-Sung Park,Björn Arns,Thora Lohnau,Justus L. Groen,Meike Kasten,Norbert Brüggemann,Johann Hagenah,Alexander Schmidt,Frank J. Kaiser,Kishore R. Kumar,Kishore R. Kumar,Katja Zschiedrich,Daniel Alvarez-Fischer,Eckart Altenmüller,Andreas Ferbert,Anthony E. Lang,Alexander Münchau,Vladimir S. Kostic,Kristina Simonyan,Marc Agzarian,Laurie J. Ozelius,Antonius P. M. Langeveld,Carolyn M. Sue,Marina A. J. Tijssen,Christine Klein +30 more
TL;DR: A study was undertaken to identify the gene underlying DYT4 dySTONia, a dominantly inherited form of spasmodic dysphonia combined with other focal or generalized dystonia and a characteristic facies and body habitus in an Australian family.
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The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms
TL;DR: A new understanding is provided of the role that ATP13A2 plays in the development of PD and a therapeutic target is identified that may ameliorate α‐synuclein accumulation and lysosomal and mitochondrial dysfunction in Parkinson's disease.