A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism
Keiichi Inoue,Keiichi Inoue,Keiichi Inoue,Yuko Mikuni-Takagaki,Kaoru Oikawa,Takeshi Itoh,Masaki Inada,Takanori Noguchi,Jin-Sung Park,Jin-Sung Park,Takashi Onodera,Stephen M. Krane,Masaki Noda,Shigeyoshi Itohara +13 more
TLDR
It is proposed that osteocytic network formation is a determinant of bone remodeling and mineralization and that MMP-2 plays a crucial role in forming and maintaining the osteocytics canalicular network.About:
This article is published in Journal of Biological Chemistry.The article was published on 2006-11-03 and is currently open access. It has received 184 citations till now. The article focuses on the topics: Bone cell & Bone remodeling.read more
Citations
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Journal ArticleDOI
Matrix metalloproteinases and the regulation of tissue remodelling
TL;DR: Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.
Journal ArticleDOI
Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.
TL;DR: Genomic analyses have been further extended through the generation of animal models of gain- or loss-of-function for MMPs which have allowed the identification of novel functions for these enzymes and the establishment of causal relationships between MMP dysregulation and development of different human diseases.
Journal ArticleDOI
Breaching the basement membrane: who, when and how?
R. Grant Rowe,Stephen J. Weiss +1 more
TL;DR: New data indicate that protease-dependent transmigration is largely reliant on a group of membrane-anchored metalloenzymes, termed the membrane-type matrix metalloproteinases, which irreversibly remodel BM structure.
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Osteocytes: Master Orchestrators of Bone
TL;DR: How a highly productive combination of experimental and theoretical approaches has managed to unearth unique features of osteocytes and bring to light novel insights into the regulatory mechanisms operating in bone is discussed.
Journal ArticleDOI
Osteocyte: the unrecognized side of bone tissue.
TL;DR: The outcome of micro-cracks in the vicinity of osteocytes may interrupt the canalicular network and trigger cell apoptosis in the immediate surrounding environment, and this apoptosis appears to transmit a message to the bone surface and activate remodeling.
References
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Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee
A. Michael Parfitt,Marc K. Drezner,Francis H. Glorieux,John A. Kanis,Hartmut H. Malluche,Pierre J. Meunier,Susan M. Ott,Robert R. Recker +7 more
TL;DR: A committee of the Society to develop a unified system of termnology, suitable for adoption by the Journal of Bone and Mineral Research as part of its Instructions to Authors is formed, and is as complex and conceptually difficult as the field with which it deals.
Journal ArticleDOI
A matrix metalloproteinase expressed on the surface of invasive tumour cells
Hiroshi Sato,Takahisa Takino,Yasunori Okada,Jian Cao,Akira Shinagawa,Etsuhide Yamamoto,Motoharu Seiki +6 more
TL;DR: The cloning of the complemen-tary DNA encoding a new matrix metalloproteinase with a potential transmembrane domain is reported, which may trigger invasion by tumour cells by activating pro-gelatinase A on the tumour cell surface.
BookDOI
Principles of bone biology
TL;DR: Basic principles - cell biology biochemistry bone re-modelling and mineral homeostasis the hormones of bone other systemic hormones that influence bone metabolism local regulators of bone molecular mechanisms of metabolic bone diseases pharmacological mechanisms of therapeutics methods in bone research.
Journal ArticleDOI
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
Kenn Holmbeck,Paolo Bianco,John J. Caterina,Susan Yamada,Mark Kromer,Sergei A. Kuznetsov,Mahesh H. Mankani,Pamela Gehron Robey,A. Robin Poole,Isabelle Pidoux,Jerrold M. Ward,Henning Birkedal-Hansen +11 more
TL;DR: The findings demonstrate the pivotal function of MT1-MMP in connective tissue metabolism, and illustrate that modeling of the soft connective tissues matrix by resident cells is essential for the development and maintenance of the hard tissues of the skeleton.