J
Jo Spencer
Researcher at King's College London
Publications - 171
Citations - 12045
Jo Spencer is an academic researcher from King's College London. The author has contributed to research in topics: B cell & Antibody. The author has an hindex of 48, co-authored 156 publications receiving 11345 citations. Previous affiliations of Jo Spencer include University College London & Guy's and St Thomas' NHS Foundation Trust.
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Journal ArticleDOI
Immunoproliferative small-intestinal disease. An immunohistochemical study.
TL;DR: Findings confirm the homology between IPSID and low-grade B-cell "Western" lymphomas arising in mucosa-associated lymphoid tissue and suggest that the follicular pattern sometimes seen in these lymphomas is caused by selective colonization of reactive follicles by CCL tumor cells.
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Malignant lymphoma of mucosa‐associated lymphoid tissue
Peter G. Isaacson,Jo Spencer +1 more
TL;DR: In this paper their morphological features are reviewed; recent findings based on immunohistochemistry and DNA analysis are presented; and the biological behaviour of these tumours is discussed insofar as they offer insight into mucosal immunological mechanisms.
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The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori
TL;DR: The response of low-grade B-cell gastric MALT lymphomas to stimulating strains of H pylori is dependent on H-pylori-specific T cells and their products, rather than the bacteria themselves.
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Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
Frances Humby,Michele Bombardieri,Antonio Manzo,Stephen Kelly,Mark Blades,Bruce Kirkham,Jo Spencer,Costantino Pitzalis +7 more
TL;DR: It is demonstrated that FDC+ follicular units invariably express AID and are surrounded by ACPA-producing plasma cells, providing strong evidence that ectopic lymphoid structures in the RA synovium are functional and support autoantibody production.
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Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine.
Thomas T. MacDonald,Jo Spencer +1 more
TL;DR: These experiments show that activated T cells in human small intestine produce enteropathy, and the model provides a new system with which to dissect the mechanisms of T cell-mediated intestinal damage.