J
João T. Barata
Researcher at Instituto de Medicina Molecular
Publications - 99
Citations - 4619
João T. Barata is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Leukemia & T cell. The author has an hindex of 36, co-authored 86 publications receiving 3956 citations. Previous affiliations of João T. Barata include University of Lisbon & Harvard University.
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Journal ArticleDOI
PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability.
Ana Elisa Bauer de Camargo Silva,J. Andrés Yunes,Bruno A. Cardoso,Leila R. Martins,Patrícia Y. Jotta,Miguel Abecasis,Alexandre E. Nowill,Nick R. Leslie,Angelo A. Cardoso,João T. Barata +9 more
TL;DR: Overall, the data indicate that T-ALL cells inactivate PTEN mostly in a nondeletional, posttranslational manner, and Pharmacological manipulation of these mechanisms may open new avenues for T-all treatment.
Journal ArticleDOI
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.
Priscila Pini Zenatti,Daniel Dias Ribeiro,Wenqing Li,Linda Zuurbier,Milene Costa da Silva,Maddalena Paganin,Julia Tritapoe,Julie A. Hixon,André B. Silveira,Bruno A. Cardoso,Leonor M. Sarmento,Nádia C. Correia,María L. Toribio,Joerg Kobarg,Martin A. Horstmann,Rob Pieters,Silvia Regina Brandalise,Adolfo A. Ferrando,Jules P.P. Meijerink,Scott K. Durum,J. Andrés Yunes,João T. Barata +21 more
TL;DR: The findings indicate that IL7R mutational activation is involved in human T-cell leukemogenesis, paving the way for therapeutic targeting of IL-7R–mediated signaling in T-ALL.
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Activation of PI3K Is Indispensable for Interleukin 7–mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells
João T. Barata,Ana Elisa Bauer de Camargo Silva,Joana G. Brandao,Lee M. Nadler,Angelo A. Cardoso,Vassiliki A. Boussiotis +5 more
TL;DR: PI3K is implicate as a major effector of IL-7–induced viability, metabolic activation, growth and proliferation of T-ALL cells, and suggest that PI3K and its downstream effectors may represent molecular targets for therapeutic intervention in T-all.
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Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27kip1
TL;DR: This study shows that in the presence of IL-7, T-ALL cells not only up-regulated bcl-2 expression and escaped apoptosis but also progressed in the cell cycle, resulting in sequential induction of cyclin D2 and cyclin A.
Journal ArticleDOI
Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesis.
Inês Sofia Vala,Leila R. Martins,Natsuko Imaizumi,Raquel J. Nunes,José Pedro Rino,François Kuonen,Lara Carvalho,Curzio Rüegg,Isabel Monteiro Grillo,João T. Barata,Marc Mareel,Susana Constantino Rosa Santos +11 more
TL;DR: It is shown that low-dose IR promotes tumor growth and metastasis and that these effects were prevented by the administration of a VEGF receptor-tyrosine kinase inhibitor immediately before IR exposure, demonstrating a new mechanism to the understanding of the potential pro-metastatic effect of IR.