J
Johannes F. Scheid
Researcher at Harvard University
Publications - 56
Citations - 10968
Johannes F. Scheid is an academic researcher from Harvard University. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 36, co-authored 50 publications receiving 9736 citations. Previous affiliations of Johannes F. Scheid include Howard Hughes Medical Institute & Rockefeller University.
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Journal ArticleDOI
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01.
Tongqing Zhou,Ivelin S. Georgiev,Xueling Wu,Zhi Yong Yang,Kaifan Dai,Andrés Finzi,Young Do Kwon,Johannes F. Scheid,Wei Shi,Ling Xu,Yongping Yang,Jiang Zhu,Michel C. Nussenzweig,Joseph Sodroski,Lawrence Shapiro,Lawrence Shapiro,Gary J. Nabel,John R. Mascola,Peter D. Kwong +18 more
TL;DR: The identification of three broadly neutralizing antibodies, isolated from an HIV-1–infected individual, that exhibited great breadth and potency of neutralization and were specific for the co-receptor CD4-binding site of the glycoprotein 120 (gp120), part of the viral Env spike.
Journal ArticleDOI
Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Johannes F. Scheid,Hugo Mouquet,Beatrix Ueberheide,Ron Diskin,Florian Klein,Thiago Y. Oliveira,John Pietzsch,John Pietzsch,David Fenyö,Alexander Abadir,Klara Velinzon,Arlene Hurley,Sunnie Myung,Farid Boulad,Pascal Poignard,Pascal Poignard,Dennis R. Burton,Dennis R. Burton,Florencia Pereyra,Florencia Pereyra,David D. Ho,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Michael S. Seaman,Pamela J. Bjorkman,Pamela J. Bjorkman,Brian T. Chait,Michel C. Nussenzweig,Michel C. Nussenzweig +29 more
TL;DR: Anti-HIV broadly neutralizing antibodies with similar specificities and modes of binding were found in multiple HIV-infected individuals, and cloned 576 new HIV antibodies from four unrelated individuals to determine whether they are part of a larger group of related molecules.
Journal ArticleDOI
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
Johannes F. Scheid,Hugo Mouquet,Niklas Feldhahn,Michael S. Seaman,Klara Velinzon,John Pietzsch,Rene G. Ott,Robert M. Anthony,Henry Zebroski,Arlene Hurley,Adhuna Phogat,Bimal K. Chakrabarti,Yuxing Li,Mark Connors,Florencia Pereyra,Bruce D. Walker,Hedda Wardemann,David D. Ho,Richard T. Wyatt,John R. Mascola,Jeffrey V. Ravetch,Michel C. Nussenzweig +21 more
TL;DR: The IgG memory B-cell compartment in the selected group of patients with broad serumneutralizing activity to HIV is comprised of multiple clonal responses with neutralizing activity directed against several epitopes on gp120.
Journal ArticleDOI
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
Marina Caskey,Florian Klein,Julio C. C. Lorenzi,Michael S. Seaman,Anthony P. West,Noreen Buckley,Gisela Kremer,Lilian Nogueira,Malte Braunschweig,Johannes F. Scheid,Joshua A. Horwitz,Irina Shimeliovich,Sivan Ben-Avraham,Maggi Witmer-Pack,Martin Platten,Clara Lehmann,Leah A. Burke,Thomas Hawthorne,Robert J. Gorelick,Bruce D. Walker,Tibor Keler,Roy M. Gulick,Gerd Fätkenheuer,Sarah J. Schlesinger,Michel C. Nussenzweig +24 more
TL;DR: It is concluded that, as a single agent, 3BNC117 is safe and effective in reducing HIV-1 viraemia, and that immunotherapy should be explored as a new modality for HIV- 1 prevention, therapy and cure.
Journal ArticleDOI
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies.
Hugo Mouquet,Louise Scharf,Zelda Euler,Yan Liu,Caroline Eden,Johannes F. Scheid,Johannes F. Scheid,Ariel Halper-Stromberg,Priyanthi N. P. Gnanapragasam,Daniel I. R. Spencer,Michael S. Seaman,Hanneke Schuitemaker,Ten Feizi,Michel C. Nussenzweig,Pamela J. Bjorkman +14 more
TL;DR: As HIV envelopes exhibit varying proportions of high-mannose- and complex-type N-glycans, these results suggest promiscuous carbohydrate interactions, an advantageous adaptation ensuring neutralization of all viruses within a given strain.