J
John P. Iredale
Researcher at University of Bristol
Publications - 221
Citations - 26200
John P. Iredale is an academic researcher from University of Bristol. The author has contributed to research in topics: Hepatic stellate cell & Fibrosis. The author has an hindex of 77, co-authored 221 publications receiving 23394 citations. Previous affiliations of John P. Iredale include University College London & University of Cambridge.
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Journal ArticleDOI
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Jeremy S. Duffield,Stuart J. Forbes,Christothea M. Constandinou,Spike Clay,Marina Partolina,Srilatha Vuthoori,Shengji Wu,Richard A. Lang,John P. Iredale +8 more
TL;DR: These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophage play critical roles in both the injury and recovery phases of inflammatory scarring.
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Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.
John P. Iredale,RC Benyon,Judith A. Pickering,M. Mccullen,M. Northrop,S. Pawley,Christopher J. Hovell,Michael J. P. Arthur +7 more
TL;DR: It is suggested that apoptosis of activated HSC may vitally contribute to resolution of fibrosis by acting as a mechanism for removing the cell population responsible for both producing fibrotic neomatrix and protecting this matrix from degradation via their production of TIMPs.
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Liver fibrosis and repair: immune regulation of wound healing in a solid organ
TL;DR: This Review focuses on recent advances in liver fibrosis research as a paradigm for wound healing in solid organs and the role of the immune system in regulating and balancing this response.
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Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
TL;DR: The manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ is highlighted.
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Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
Prakash Ramachandran,Antonella Pellicoro,Madeleine A. Vernon,Luke Boulter,Rebecca L. Aucott,Aysha Ali,Stephen N. Hartland,Victoria K. Snowdon,Andrea Cappon,Timothy T. Gordon-Walker,Mike J. Williams,Donald R. Dunbar,Jonathan R. Manning,Nico van Rooijen,Jonathan A. Fallowfield,Stuart J. Forbes,John P. Iredale +16 more
TL;DR: The restorative macrophage phenotype was recapitulated in vitro by the phagocytosis of cellular debris with associated activation of the ERK signaling cascade, offering a therapeutic strategy to this orphan pathological process.