Yin Cao

TL;DR: It was found that higher neoantigen load was positively associated with overall lymphocytic infiltration, tumor-infiltrating lymphocytes, memory T cells, and CRC-specific survival and positive selection of mutations in HLA genes and other components of the antigen-processing machinery in TIL-rich tumors.

TL;DR: The amount of F. nucleatum DNA in colorectal cancer tissue is associated with shorter survival, and may potentially serve as a prognostic biomarker, which may have implications in developing cancer prevention and treatment strategies through targeting GI microflora by diet, probiotics and antibiotics.

TL;DR: A random-effects meta-analysis used to assess the relative risks of prostate cancer-specific mortality and biochemical recurrence associated with a 5 kg/m2 increase in BMI found Elevated BMI is associated with risk of prostate Cancer–specific mortality in prospective cohort studies and biochemicalRecurrence in prostate cancer patients.

TL;DR: Given the known hazards of long-term aspirin use, larger-scale adoption of an aspirin chemoprevention strategy is likely to require improved identification of individuals for whom the protective benefits outweigh the harms, and a precision medicine approach may emerge through further clarification of aspirin's mechanism of action.

TL;DR: A serial, cross-sectional analysis of the US nationally representative data from the National Health and Nutrition Examination Survey (NHANES) among children aged 5 through 11 years, adolescents, 12 through 19 years, and adults, 20 years or older from 2001 through 2016 to evaluate patterns and temporal trends in sedentary behaviors and sociodemographic and lifestyle correlates in the US population.