Josef Frank

TL;DR: In this paper, the authors identified differentially expressed (DE) genes in the ventral and dorsal striatum between individuals with AUD and controls, and integrated the results with findings from genome and epigenome-wide association studies (GWAS/EWAS) to identify functionally relevant molecular mechanisms of AUD.

TL;DR: In this article , the authors focus on early childhood, and investigate urbanicity, behavior problems and the regulation of the hypothalamus-pituitary-adrenal (HPA) axis, a central circuit of the stress system.

TL;DR: In this paper , the authors performed extensive profiling of postmortem human brain tissue by analyzing the genome, epigenome, and transcriptome in the striatum of individuals with and without AUD, and assessed telomere length, mitochondrial DNA copy numbers, and epigenetic clocks to investigate inflammation and aging as potential long-term correlates of AUD in the brain.

TL;DR: In this article, the authors investigated the association between the microbiota and cognitive functioning of children at the age of 45 months measured with the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III).

TL;DR: In this article , the authors used the GWAS and Sequencing Consortium of Alcohol and Nicotine (GSCAN) Consortium were used to calculate polygenic risk scores (PRS) in a sample of ~2,200 smokers/never-smokers.