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Josef Frank

Researcher at Heidelberg University

Publications -  171
Citations -  23450

Josef Frank is an academic researcher from Heidelberg University. The author has contributed to research in topics: Genome-wide association study & Bipolar disorder. The author has an hindex of 41, co-authored 142 publications receiving 18096 citations.

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The association between genetic variability in the NPS/NPSR1 system and chronic stress responses: A gene-environment-(quasi-) experiment

TL;DR: In this article , the authors investigated the association between overall genetic variability in the NPS/NPSR1 system and psychological and cortisol stress regulation in everyday life and found a significant GxE interaction for the area under the curve with respect to the ground.
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Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability.

Xiaotong Wang, +199 more
TL;DR: In this article , the authors show that if heterogeneities in cohort-specific h S N P 2 exist, or if genetic correlations between cohorts are less than one, the out-of-sample prediction R2 will be greater than h S n P 2 and show the validity of their derivations with real data from a binary trait (major depression) and a continuous trait (educational attainment).
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Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants

TL;DR: In this article , the authors measured fast sleep spindles in 150 healthy adults and investigated its association with a genome-wide polygenic score for schizophrenia (SCZ-PGS).
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Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions

Eduardo A Maury, +361 more
- 01 Jul 2023 - 
TL;DR: In this article , the authors identified sCNVs using blood-derived genotype arrays from 12,834 schizophrenia cases and 11,648 controls, filtering them at loci recurrently mutated in clonal blood disorders.