J
Josef Frank
Researcher at Heidelberg University
Publications - 171
Citations - 23450
Josef Frank is an academic researcher from Heidelberg University. The author has contributed to research in topics: Genome-wide association study & Bipolar disorder. The author has an hindex of 41, co-authored 142 publications receiving 18096 citations.
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Journal ArticleDOI
The association between genetic variability in the NPS/NPSR1 system and chronic stress responses: A gene-environment-(quasi-) experiment
Hannah Peter,Marina Giglberger,Josef Frank,Fabian Streit,Sandra Zänkert,Ludwig Kreuzpointner,Marcella Rietschel,Brigitte M. Kudielka,Stefan Wüst +8 more
TL;DR: In this article , the authors investigated the association between overall genetic variability in the NPS/NPSR1 system and psychological and cortisol stress regulation in everyday life and found a significant GxE interaction for the area under the curve with respect to the ground.
Journal ArticleDOI
Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability.
Xiaotong Wang,Joana A. Revez,Guiyan Ni,Mark Adams,Andrew M. McIntosh,Peter M. Visscher,Naomi R. Wray,Stephan Ripke,Manuel Mattheisen,Maciej Trzaskowski,Enda M. Byrne,Abdel Abdellaoui,Esben Agerbo,Tracy Air,Till F. M. Andlauer,Silviu Alin Bacanu,Marie Bækvad-Hansen,Aartjan T.F. Beekman,Tim B. Bigdeli,Elisabeth B. Binder,Julien Bryois,Henriette N. Buttenschøn,Jonas Bybjerg-Grauholm,Na Cai,Enrique Castelao,Jane H. Christensen,Toni-Kim Clarke,Jonathan R. I. Coleman,Lucía Colodro-Conde,Baptiste Couvy-Duchesne,Nicholas John Craddock,Gregory E. Crawford,Gail Davies,Franziska Degenhardt,Eske M. Derks,Nese Direk,Conor V. Dolan,Erin C. Dunn,Thalia C. Eley,Valentina Escott-Price,Farnush Farhadi Hassan Kiadeh,Hilary K. Finucane,Jerome C. Foo,Andreas J. Forstner,Josef Frank,Helena Gaspar,Michael Gill,Fernando S. Goes,Scott D. Gordon,Jakob Grove,Lynsey S. Hall,Christine Søholm Hansen,Thomas Hansen,Stefan Herms,Ian B. Hickie,Per Hoffmann,Georg Homuth,Carsten Horn,Jouke-Jan Hottenga,David M. Hougaard,David Howard,Marcus Ising,Rick Jansen,Ian Jones,Lisa Jones,Eric Jorgenson,James A. Knowles,Isaac S. Kohane,Julia Kraft,Warren W. Kretzschmar,Zoltán Kutalik,Yihan Li,Penelope A. Lind,Donald J. MacIntyre,Dean F. MacKinnon,Robert Maier,Wolfgang Maier,Jonathan Marchini,Hamdi Mbarek,Patrick J. McGrath,Peter McGuffin,Sarah E. Medland,Divya Mehta,Christel M. Middeldorp,Evelin Mihailov,Yuri Milaneschi,Lili Milani,Francis M. Mondimore,Grant W. Montgomery,Sara Mostafavi,Niamh Mullins,Matthias Nauck,Bernard Ng,Michel G. Nivard,Dale R. Nyholt,Paul F. O'Reilly,Hogni Oskarsson,Michael John Owen,Jodie N. Painter,Carsten Bøcker Pedersen,Marianne Giørtz Pedersen,Roseann E. Peterson,Wouter J. Peyrot,Giorgio Pistis,Danielle Posthuma,Jorge A. Quiroz,Per Qvist,John P. Rice,Brien P. Riley,Margarita Rivera,Saira Saeed Mirza,Robert A. Schoevers,Eva C. Schulte,Ling Shen,Jianxin Shi,Stanley I. Shyn,Engilbert Sigurdsson,Grant Sinnamon,Jan Smit,Daniel J. Smith,Hreinn Stefansson,Stacy Steinberg,Fabian Streit,Jana Strohmaier,Katherine E. Tansey,Henning Teismann,Alexander Teumer,Wesley K. Thompson,Pippa A. Thomson,Thorgeir E. Thorgeirsson,Matthew Traylor,Jens Treutlein,Vassily Trubetskoy,André G. Uitterlinden,Daniel Umbricht,Sandra Van der Auwera,Albert M. van Hemert,Alexander Viktorin,Yunpeng Wang,Bradley T. Webb,Shantel Weinsheimer,Jürgen Wellmann,Gonneke Willemsen,Stephanie H. Witt,Yang Wu,Hualin Simon Xi,Jian Yang,Futao Zhang,Volker Arolt,Bernhard T. Baune,Klaus Berger,Dorret I. Boomsma,Sven Cichon,Udo Dannlowski,Eco J. C. de Geus,J. Raymond DePaulo,Enrico Domenici,Katharina Domschke,Tõnu Esko,Hans J. Grabe,Steven P. Hamilton,Caroline Hayward,Andrew C. Heath,Kenneth S. Kendler,Stefan Kloiber,Glyn Lewis,Qingqin S. Li,Susanne Lucae,Pamela A. F. Madden,Patrik K. E. Magnusson,Nicholas G. Martin,Andres Metspalu,Ole Mors,Preben Bo Mortensen,Bertram Müller-Myhsok,Merete Nordentoft,Markus M. Nöthen,Michael Conlon O'Donovan,Sara A. Paciga,Nancy L. Pedersen,Brenda W.J.H. Penninx,Roy H. Perlis,David J. Porteous,James B. Potash,Martin Preisig,Marcella Rietschel,Catherine Schaefer,Thomas G. Schulze,Jordan W. Smoller,Kari Stefansson,Henning Tiemeier,Rudolf Uher,Henry Völzke,Myrna M. Weissman,Thomas Werge,Cathryn M. Lewis,Douglas F. Levinson,Gerome Breen,Anders D. Børglum,Patrick F. Sullivan +199 more
TL;DR: In this article , the authors show that if heterogeneities in cohort-specific h S N P 2 exist, or if genetic correlations between cohorts are less than one, the out-of-sample prediction R2 will be greater than h S n P 2 and show the validity of their derivations with real data from a binary trait (major depression) and a continuous trait (educational attainment).
Journal ArticleDOI
Gene x environment interactions in depression: the role of family history and early trauma – an investigation in the german national cohort (nako)
Maja Völker,Fabian Streit,Johanna Klinger-König,Lea Zillich,Josef Frank,Nako Expert Group Neurologic-Psychiatric Disorders,Klaus Berger,Hans J. Grabe,Marcella Rietschel +8 more
Journal ArticleDOI
Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants
Claudia Schilling,Lea Zillich,Michael Schredl,Josef Frank,Emanuel Schwarz,Michael Deuschle,Andreas Meyer-Lindenberg,Marcella Rietschel,Stephanie H. Witt,Fabian Streit +9 more
TL;DR: In this article , the authors measured fast sleep spindles in 150 healthy adults and investigated its association with a genome-wide polygenic score for schizophrenia (SCZ-PGS).
Journal ArticleDOI
Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions
Eduardo A Maury,Maxwell A. Sherman,Giulio Genovese,Thomas G. Gilgenast,Tushar Kamath,SJ Burris,Prashanth Rajarajan,Erin Flaherty,Schahram Akbarian,Andrew Chess,Steven A. McCarroll,Po-ru Loh,Jennifer E. Phillips-Cremins,Kristen J. Brennand,Evan Z. Macosko,James T.R. Walters,Michael Conlon O'Donovan,Patrick F. Sullivan,Jonathan Sebat,Eunjung Lee,Christopher A. Walsh,Christian R. Marshall,Daniele Merico,Bhooma Thiruvahindrapuram,Zhouzhi Wang,Stephen W. Scherer,Daniel P. Howrigan,Stephan Ripke,Brendan Bulik-Sullivan,Kai-How Farh,Menachem Fromer,Jackie Goldstein,Hailiang Huang,Phil Lee,Mark J. Daly,Benjamin M. Neale,Richard A. Belliveau,Sarah E. Bergen,Elizabeth Bevilacqua,Kimberly Chambert,Colm O'Dushlaine,Edward M. Scolnick,Jordan W. Smoller,Jennifer L. Moran,Aarno Palotie,Tracey L. Petryshen,Wenting Wu,Douglas S. Greer,Danny Antaki,Aniket Shetty,Madhu Gujral,William M. Brandler,Dheeraj Malhotra,Michelle S. Maile,Peter Holmans,Noa Carrera,Nicholas John Craddock,Valentina Escott-Price,Lyudmila Georgieva,Marian L. Hamshere,David J. Kavanagh,Sophie E. Legge,Andrew Pocklington,Alexander Richards,Douglas M. Ruderfer,Nigel Williams,George Kirov,Michael John Owen,Dalila Pinto,Guiqing Cai,Kenneth L. Davis,Elodie Drapeau,Joseph H. Friedman,Vahram Haroutunian,Elena Parkhomenko,Abraham Reichenberg,Jeremy M. Silverman,Joseph D. Buxbaum,Enrico Domenici,Ingrid Agartz,Srdjan Djurovic,Morten Mattingsdal,Ingrid Melle,Ole A. Andreassen,Erik G. Jönsson,Erik Söderman,Margot Albus,Madeline Alexander,Claudine Laurent,Douglas F. Levinson,Farooq Amin,Joshua R. Atkins,Murray J. Cairns,Rodney J. Scott,Paul A. Tooney,Jing Qin Wu,Silviu Alin Bacanu,Tim B. Bigdeli,Mark Reimers,Bradley T. Webb,Aaron R. Wolen,Brandon Wormley,Kenneth S. Kendler,Brien P. Riley,Anna K. Kähler,Patrik K. E. Magnusson,Christina M. Hultman,Marcelo Bertalan,Thomas Hansen,Line Olsen,Henrik B. Rasmussen,Thomas Werge,Manuel Mattheisen,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,Joshua L. Roffman,William Byerley,Wiepke Cahn,René S. Kahn,Eric Strengman,Roel A. Ophoff,Vaughan J. Carr,Stanley V. Catts,Frans Henskens,Carmel M. Loughland,Patricia T. Michie,Christos Pantelis,Ulrich Schall,Assen Jablensky,Brian J. Kelly,Dominique Campion,Rita M. Cantor,Wei Cheng,C. Robert Cloninger,Dragan M. Svrakic,David Cohen,Paul Cormican,Gary Donohoe,Derek W. Morris,Aiden Corvin,Michael Gill,Benedicto Crespo-Facorro,James J. Crowley,Martilias S. Farrell,Paola Giusti-Rodríguez,Yunjung Kim,Jin P. Szatkiewicz,Stephanie Williams,David Curtis,Jonathan Pimm,Hugh Gurling,Andrew McQuillin,Michael H. Davidson,Mark Weiser,Franziska Degenhardt,Andreas J. Forstner,Stefan Herms,Per Hoffmann,A. Hofman,Sven Cichon,Markus M. Nöthen,Jurgen Del Favero,Lynn E. DeLisi,Robert W. McCarley,Deborah L. Levy,Raquelle I. Mesholam-Gately,Larry J. Seidman,Dimitris Dikeos,George N. Papadimitriou,Timothy G. Dinan,Jubao Duan,Alan R. Sanders,Pablo V. Gejman,Elliot S. Gershon,Frank Dudbridge,Peter Eichhammer,Johan Holmberg Eriksson,Veikko Salomaa,Laurent Essioux,Ayman H. Fanous,James A. Knowles,Michele T. Pato,Carlos N. Pato,Josef Frank,Sandra Meier,Thomas G. Schulze,Jana Strohmaier,Stephanie H. Witt,Marcella Rietschel,Lude Franke,Juha Karjalainen,Robert Freedman,Ann Olincy,Nelson B. Freimer,Shaun Purcell,Panos Roussos,Eli A. Stahl,Pamela Sklar,Ina Giegling,T. Hartmann,Bettina Konte,Dan Rujescu,Stephanie Godard,Joel N. Hirschhorn,Tune H. Pers,Alkes Price,Tõnu Esko,Jacob Gratten,S. Hong Lee,Peter M. Visscher,Naomi R. Wray,Bryan J. Mowry,Lieuwe de Haan,Carin J. Meijer,M. Hansen,Masashi Ikeda,Nakao Iwata,Inge Joa,Luba Kalaydjieva,Matthew C. Keller,James L. Kennedy,Clement C. Zai,Jo Knight,Bernard Lerer,Kung-Yee Liang,Jeffrey A. Lieberman,T. Scott Stroup,Jouko Lönnqvist,Jaana Suvisaari,Brion S. Maher,Wolfgang Maier,Jacques Mallet,Colm McDonald,Andrew M. McIntosh,Douglas Blackwood,Andres Metspalu,Lili Milani,Vihra Milanova,Younes Mokrab,David A. Collier,Bertram Müller-Myhsok,Kieran C. Murphy,Robin M. Murray,John Powell,Inez Myin-Germeys,Jim van Os,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Ann E. Pulver,Kristin K. Nicodemus,Laura Nisenbaum,Annelie Nordin,Rolf Adolfsson,Eadbhard O'Callaghan,Sang Oh,F. Anthony O'Neill,Tiina Paunio,Olli Pietiläinen,Diana O. Perkins,Digby Quested,Adam Savitz,Qingqin S. Li,Sibylle G. Schwab,Jianxin Shi,Chris C. A. Spencer,Srinivasa Thirumalai,Juha Veijola,John L. Waddington,Dermot Walsh,Dieter B. Wildenauer,Elvira Bramon,Ariel Darvasi,Danielle Posthuma,David St Clair,Omar Shanta,Marieke Klein,Peter J. Park,Daniel R. Weinberger,John V. Moran,Fred H. Gage,Flora M. Vaccarino,J. Gleeson,G D Mathern,Eric Courchesne,Subhojit Roy,Sara Bizzotto,Michael E. Coulter,Caroline Dias,Alissa M. D'Gama,Javier Ganz,R. Sean Hill,August Yue Huang,Sattar Khoshkhoo,Sonia N. Kim,Michael A. Lodato,Rebeca Borges-Monroy,Rachel E. Rodin,Zinan Zhou,Craig L. Bohrson,Chong Wei Chu,Isidro Cortes-Ciriano,Yanmei Dou,Alon Galor,Doga Gulhan,Minseok Kwon,Joe J Luquette,Vinay Viswanadham,Attila G. Jones,Chaggai Rosenbluh,Sea Eun Cho,Ben Langmead,Jeremy Thorpe,Jennifer A. Erwin,Andrew E. Jaffe,Michael Stewart McConnell,Rujuta Narurkar,Apuã C. M. Paquola,Richard E. Straub,Alexej Abyzov,Taejeong Bae,Yeongjun Jang,Yifan Wang,Sara B. Linker,Patrick Reed,Mei-Ling Wang,Alexander E. Urban,Bo Zhou,Xiaowei Zhu,Reenal Pattni,Aitor Serres Amero,David Juan,Irene Lobon,Tomas Marques-Bonet,Manuel Solis Moruno,Raquel Garcia Perez,Inna S. Povolotskaya,Eduardo Soriano,Dan Averbuj,Laurel L. Ball,Martin W. Breuss,Xiaoxu Yang,Changuk Chung,Sarah B. Emery,Diane Flasch,Jeffrey M. Kidd,Huira C. Kopera,Kenneth Y. Kwan,Ryan E. Mills,John B. Moldovan,Chen Sun,Xuefang Zhao,Weichen Zhou,Trent Frisbie,Adriana Cherskov,Liana Fasching,Alexandre Jourdon,Sirisha Pochareddy,Soraya Scuderi,Nenad Sestan +361 more
TL;DR: In this article , the authors identified sCNVs using blood-derived genotype arrays from 12,834 schizophrenia cases and 11,648 controls, filtering them at loci recurrently mutated in clonal blood disorders.