J
Josef Frank
Researcher at Heidelberg University
Publications - 171
Citations - 23450
Josef Frank is an academic researcher from Heidelberg University. The author has contributed to research in topics: Genome-wide association study & Bipolar disorder. The author has an hindex of 41, co-authored 142 publications receiving 18096 citations.
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Journal ArticleDOI
Longer telomere length in patients with schizophrenia.
Vanessa Nieratschker,Vanessa Nieratschker,Jenni Lahtinen,Sandra Meier,Jana Strohmaier,Josef Frank,Angela Heinrich,René Breuer,Stephanie H. Witt,Markus M. Nöthen,Marcella Rietschel,Iiris Hovatta,Iiris Hovatta +12 more
TL;DR: In contrast to previous findings, SCZ patients displayed longer telomeres compared to controls, and no association was found with any SCZ-severity subphenotype.
Journal ArticleDOI
aCaMKII Autophosphorylation Controls the Establishment of Alcohol Drinking Behavior
Alanna C. Easton,Walter Lucchesi,Anbarasu Lourdusamy,Bernd Lenz,Jalal Solati,Yulia Golub,Piotr Lewczuk,Cathy Fernandes,Sylvane Desrivières,R R Dawirs,Gunther H. Moll,Johannes Kornhuber,Josef Frank,Per Hoffmann,Michael Soyka,Falk Kiefer,Gunter Schumann,K. Peter Giese,Christian P. Müller,Christian P. Müller +19 more
TL;DR: The data suggest αCaMKII autophosphorylation as a facilitating mechanism in the establishment of alcohol drinking behavior with changing the DA–5-HT balance as a putative mechanism.
Journal ArticleDOI
Studies in Humans and Mice Implicate Neurocan in the Etiology of Mania
Xavier Miró,Sandra Meier,Marie Luise Dreisow,Josef Frank,Jana Strohmaier,René Breuer,Christine Schmäl,Onder Albayram,María Teresa Pardo-Olmedilla,Thomas W. Mühleisen,Franziska Degenhardt,Manuel Mattheisen,Iris Reinhard,Andras Bilkei-Gorzo,Sven Cichon,Constanze I. Seidenbecher,Marcella Rietschel,Markus M. Nöthen,Andreas Zimmer +18 more
TL;DR: NCAN preferentially affected mania symptoms in humans and Ncan(-/-) mice showed behavioral abnormalities that were strikingly similar to those of the human mania phenotype and may thus serve as a valid mouse model.
Journal ArticleDOI
Genetic effects influencing risk for major depressive disorder in China and Europe
Tim B. Bigdeli,Stephan Ripke,Roseann E. Peterson,Maciej Trzaskowski,S-A Bacanu,Abdel Abdellaoui,Till F. M. Andlauer,A.T.F. Beekman,Klaus Berger,Douglas Blackwood,Dorret I. Boomsma,Gerome Breen,Henriette N. Buttenschøn,Enda M. Byrne,Sven Cichon,Toni Clarke,Baptiste Couvy-Duchesne,Baptiste Couvy-Duchesne,Nicholas John Craddock,E.J.C. de Geus,E.J.C. de Geus,Franziska Degenhardt,Erin C. Dunn,Erin C. Dunn,Alexis C. Edwards,Ayman H. Fanous,Andreas J. Forstner,Josef Frank,Michael Gill,Scott D. Gordon,Hans-Jörgen Grabe,Steven P. Hamilton,Orla Hardiman,Caroline Hayward,A. C. Heath,Anjali K. Henders,Stefan Herms,Stefan Herms,Ian B. Hickie,Peter Hoffmann,Peter Hoffmann,Georg Homuth,J-J Hottenga,Marcus Ising,Rick Jansen,Stefan Kloiber,James A. Knowles,Maren Lang,Qingqin S. Li,Susanne Lucae,Donald J. MacIntyre,Peter Madden,Nicholas G. Martin,Nicholas G. Martin,Patrick J. McGrath,Peter McGuffin,Andrew M. McIntosh,Sarah E. Medland,Divya Mehta,Christel M. Middeldorp,Y. Milaneschi,Grant W. Montgomery,Ole Mors,Bertram Müller-Myhsok,Bertram Müller-Myhsok,M. Nauck,Dale R. Nyholt,M. M. Nöthen,Michael John Owen,Brenda W.J.H. Penninx,Michele L. Pergadia,Roy H. Perlis,Wouter J. Peyrot,David J. Porteous,James B. Potash,John P. Rice,Marcella Rietschel,Brien P. Riley,Margarita Rivera,Margarita Rivera,Robert A. Schoevers,Thomas G. Schulze,Jing Shi,Stanley I. Shyn,Jan Smit,Jordan W. Smoller,Jordan W. Smoller,Fabian Streit,Jana Strohmaier,Alexander Teumer,Jens Treutlein,S Van der Auwera,G van Grootheest,A.M. van Hemert,Henry Völzke,Bradley T. Webb,Myrna M. Weissman,Jürgen Wellmann,Gonneke Willemsen,Stephanie H. Witt,Douglas F. Levinson,Cathryn M. Lewis,Naomi R. Wray,Jonathan Flint,Jonathan Flint,Patrick F. Sullivan,Kenneth S. Kendler +106 more
TL;DR: A partially shared polygenic basis of MDD in East Asian and European populations is successfully demonstrated and this findings support a complex etiology for MDD and possible population differences in predisposing genetic factors.
Journal ArticleDOI
Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia.
Dilafruz Juraeva,Britta Haenisch,Marc Zapatka,Josef Frank,Stephanie H. Witt,Thomas W. Mühleisen,Jens Treutlein,Jana Strohmaier,Sandra Meier,Franziska Degenhardt,Ina Giegling,Stephan Ripke,Markus Leber,Christoph Lange,Thomas G. Schulze,Rainald Mössner,Igor Nenadic,Heinrich Sauer,Dan Rujescu,Wolfgang Maier,Anders D. Børglum,Roel A. Ophoff,Sven Cichon,Markus M. Nöthen,Marcella Rietschel,Manuel Mattheisen,Benedikt Brors +26 more
TL;DR: Application of the present hierarchical approach allowed identification of novel biological gene-sets or pathways with potential involvement in the etiology of schizophrenia, as well as replication of these findings in an independent cohort; detection of genes of interest for future follow-up studies; and the highlighting of novel genes in previously reported candidate regions for schizophrenia.