J
Josef Frank
Researcher at Heidelberg University
Publications - 171
Citations - 23450
Josef Frank is an academic researcher from Heidelberg University. The author has contributed to research in topics: Genome-wide association study & Bipolar disorder. The author has an hindex of 41, co-authored 142 publications receiving 18096 citations.
Papers
More filters
Journal ArticleDOI
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
Till F. M. Andlauer,Till F. M. Andlauer,Jose Guzman-Parra,Fabian Streit,Jana Strohmaier,María J. González,Susana Gil Flores,Francisco J. Cabaleiro Fabeiro,Francisco del Río Noriega,Fermin Perez Perez,Jesus Haro González,Guillermo Orozco Diaz,Yolanda de Diego-Otero,Berta Moreno-Kuestner,Georg Auburger,Franziska Degenhardt,Stefanie Heilmann-Heimbach,Stefan Herms,Stefan Herms,Per Hoffmann,Per Hoffmann,Per Hoffmann,Josef Frank,Jerome C. Foo,Jens Treutlein,Stephanie H. Witt,Sven Cichon,Sven Cichon,Manolis Kogevinas,Fabio Rivas,Fermín Mayoral,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Andreas J. Forstner,Markus M. Nöthen,Marcella Rietschel +35 more
TL;DR: It is demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families.
Journal ArticleDOI
Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia
Antonio F. Pardiñas,Sophie Smart,Isabella Willcocks,Peter Holmans,Charlotte Dennison,Amy Lynham,Sophie E. Legge,Bernhard T. Baune,Tim B. Bigdeli,Murray J. Cairns,Aiden Corvin,Ayman H. Fanous,Josef Frank,Brian Kelly,Andrew McQuillin,Ingrid Melle,Preben Bo Mortensen,Bryan J. Mowry,Carlos N. Pato,Sathish Periyasamy,Marcella Rietschel,Dan Rujescu,Carmen Simonsen,David St Clair,Paul A. Tooney,Jing Qin Wu,Ole A. Andreassen,Kaarina Kowalec,Patrick F. Sullivan,Robin M. Murray,Michael John Owen,James H. MacCabe,Michael Conlon O'Donovan,James T.R. Walters,Olesya Ajnakina,Luis Alameda,Thomas R. E. Barnes,Domenico Berardi,Elena Bonora,Sara Camporesi,Martine Cleusix,Philippe Conus,Benedicto Crespo-Facorro,Giuseppe D’Andrea,Arsime Demjaha,Kim Q. Do,Gillian A. Doody,Chin B. Eap,Aziz Ferchiou,Marta Di Forti,L. Guidi,Lina Homman,Raoul Jenni,Eileen M. Joyce,L Kassoumeri,Ines Khadimallah,O. Lastrina,Roberto Muratori,Handan Noyan,F. Anthony O'Neill,Baptiste Pignon,Romeo Restellini,Jean Romain Richard,Franck Schürhoff,Filip Spaniel,Andrei Szöke,Ilaria Tarricone,Andrea Tortelli,Alp Üçok,Javier Vázquez-Bourgon +69 more
TL;DR: Findings of this study based on common genetic variants indicate that TRS is heritable with a modest but significant single-nucleotide variation–based heritability.
Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated With Onset of Regular Smoking
Sarah H. Stephens,Sarah M. Hartz,Nicole R. Hoft,Nancy L. Saccone,Robin C. Corley,John K. Hewitt,Christian J. Hopfer,Naomi Breslau,Hilary Coon,Xiangning Chen,Francesca Ducci,Nicole Dueker,Nora Franceschini,Josef Frank,Younghun Han,Nadia N. Hansel,Chenhui Jiang,Tellervo Korhonen,Penelope A. Lind,Jason Z. Liu,Leo-Pekka Lyytikaeinen,Martha Michel,John R. Shaffer,Susan E. Short,Juzhong Sun,Alexander Teumer,John R. Thompson,Nicole Vogelzangs,Jacqueline M. Vink,Angela S. Wenzlaff,William Wheeler,Bao-Zhu Yang,Steven H. Aggen,Anthony J. Balmforth,Sebastian E. Baumeister,Terri H. Beaty,Daniel J. Benjamin,Andrew W. Bergen,Ulla Broms,David Cesarini,Nilanjan Chatterjee,Jingchun Chen,Yu-Ching Cheng,Sven Cichon,David Couper,Francesco Cucca,Danielle M. Dick,Tatiana Foroud,Helena Furberg,Ina Giegling,Nathan A. Gillespie,Fangyi Gu,Alistair S. Hall,Jenni Haellfors,Shizhong Han,Annette M. Hartmann,Kauko Heikkilae,Ian B. Hickie,Jouke-Jan Hottenga,Pekka Jousilahti,Marika Kaakinen,Mika Kaehoenen,Philipp Koellinger,Stephen Kittner,Bettina Konte,Maria-Teresa Landi,Tiina Laatikainen,Mark Leppert,Steven M. Levy,Rasika A. Mathias,Daniel W. McNeil,Sarah E. Medland,Grant W. Montgomery,Tanda Murray,Matthias Nauck,Kari E. North,Peter D. Paré,Michele L. Pergadia,Ingo Ruczinski,Veikko Salomaa,Jorma Viikari,Gonneke Willemsen,Kathleen C. Barnes,Eric Boerwinkle,Dorret I. Boomsma,Neil E. Caporaso,Howard J. Edenberg,Clyde Francks,Joel Gelernter,Hans Joergen Grabe,Hyman Hops,Marjo-Riitta Järvelin,Magnus Johannesson,Kenneth S. Kendler,Terho Lehtimaeki,Patrik K. E. Magnusson,Mary L. Marazita,Jonathan Marchini,Braxton D. Mitchell,Markus M. Noethen,Brenda W.J.H. Penninx,Olli T. Raitakari,Marcella Rietschel,Dan Rujescu,Nilesh J. Samani,Ann G. Schwartz,Sanjay Shete,Margaret R. Spitz,Gary E. Swan,Henry Voelzke,Juha Veijola,Qingyi Wei,Christopher I. Amos,Dale S. Cannon,Richard A. Grucza,Dorothy K. Hatsukami,Andrew Heath,Eric O. Johnson,Jaakko Kaprio,Pamela A. F. Madden,Nicholas G. Martin,Victoria L. Stevens,Robert B. Weiss,Peter Kraft,Laura J. Bierut,Marissa A. Ehringer +125 more
Journal ArticleDOI
The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample.
Vanessa Nieratschker,Josef Frank,Thomas W. Mühleisen,Jana Strohmaier,Jens R. Wendland,Johannes Schumacher,Johannes Schumacher,Jens Treutlein,René Breuer,Rami Abou Jamra,Rami Abou Jamra,Manuel Mattheisen,Stefan Herms,Christine Schmäl,Wolfgang Maier,Markus M. Nöthen,Sven Cichon,Marcella Rietschel,Thomas G. Schulze +18 more
TL;DR: COMT does not appear to be a risk factor for schizophrenia in this population of patients and a cognitive performance phenotype (Trail Marking Test) was available for a subgroup of the patients, and no association was found between the 13 markers and this phenotype.
Journal ArticleDOI
The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving.
Patrick Bach,Martina Kirsch,Sabine Hoffmann,Anne Jorde,Karl Mann,Josef Frank,Katrin Charlet,Anne Beck,Andreas Heinz,Henrik Walter,Marcella Rietschel,Falk Kiefer,Sabine Vollstädt-Klein +12 more
TL;DR: Genotype effects of four single nucleotide polymorphisms in the genes of the N‐Methyl‐d‐aspartate receptor (GRIN1, GRIN2A, GRin2C) and GRIK1 are associated with altered cue‐induced brain activation that is related to craving for alcohol and relapse risk.