J
Josef Frank
Researcher at Heidelberg University
Publications - 171
Citations - 23450
Josef Frank is an academic researcher from Heidelberg University. The author has contributed to research in topics: Genome-wide association study & Bipolar disorder. The author has an hindex of 41, co-authored 142 publications receiving 18096 citations.
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Journal ArticleDOI
Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate
Victor M. Karpyak,Joanna M. Biernacka,Jennifer R. Geske,Greg D. Jenkins,Julie M. Cunningham,Joëlle Rüegg,Olga Kononenko,Alexey A. Leontovich,Osama A. Abulseoud,Daniel K. Hall-Flavin,Larissa L. Loukianova,Terry D. Schneekloth,Michelle K. Skime,Josef Frank,Markus M. Nöthen,M. Rietschel,Falk Kiefer,Karl Mann,Richard M. Weinshilboum,Mark A. Frye,D.S. Choi +20 more
TL;DR: This is the first report of a replicated association of genetic markers with the length of abstinence in acamprosate-treated alcoholics, and the underlying mechanisms of this association and its usefulness for individualized treatment selection should follow.
Journal ArticleDOI
The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population.
Jana Strohmaier,Manfred Amelang,Ludwig A. Hothorn,Stephanie H. Witt,Vanessa Nieratschker,Daniel Gerhard,Sandra Meier,Stefan Wüst,Stefan Wüst,Josef Frank,Adrian Loerbroks,M. Rietschel,Til Stürmer,Til Stürmer,Thomas G. Schulze,Thomas G. Schulze +15 more
TL;DR: The results suggest that CACNA1C is involved in the genetic architecture of endophenotypes for affective disorders and schizophrenia, and that it shows a distinct sex-specific effect.
Journal ArticleDOI
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes
Liz Rietschel,Liz Rietschel,Fabian Streit,Gu Zhu,Kerrie McAloney,Josef Frank,Baptiste Couvy-Duchesne,Baptiste Couvy-Duchesne,Stephanie H. Witt,Tina M. Binz,John J. McGrath,John J. McGrath,John J. McGrath,Ian B. Hickie,Narelle K. Hansell,Margaret J. Wright,Nathan A. Gillespie,Nathan A. Gillespie,Andreas J. Forstner,Thomas G. Schulze,Stefan Wüst,Stefan Wüst,Markus M. Nöthen,Markus R. Baumgartner,Brian R. Walker,Andrew A Crawford,Andrew A Crawford,Lucía Colodro-Conde,Sarah E. Medland,Nicholas G. Martin,Marcella Rietschel +30 more
TL;DR: In this article, a twin study was conducted to assess the heritability of HCC and estimate the phenotypic and genetic correlation between HPA axis activity and psychological variables perceived stress, depressive symptoms, and neuroticism.
Journal ArticleDOI
Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with age.
Vanessa Nieratschker,Martin Grosshans,Josef Frank,Jana Strohmaier,Christoph von der Goltz,Osman El-Maarri,Stephanie H. Witt,Sven Cichon,Markus M. Nöthen,Falk Kiefer,Marcella Rietschel +10 more
TL;DR: The findings suggest that hypermethylation in alcohol‐dependent patients is a consequence, rather than a cause, of the disorder, and DNA methylation patterns may change over time.
Journal ArticleDOI
Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia
Andrea Schmitt,Jiri Koschel,Mathias Zink,Manfred Bauer,Clemens Sommer,Josef Frank,Jens Treutlein,Thomas G. Schulze,Thomas Schneider-Axmann,Eleni Parlapani,Marcella Rietschel,Peter Falkai,Fritz A. Henn +12 more
TL;DR: Increased NR2D expression results in a hyperexcitable NMDA receptor suggesting an adaptive effect due to receptor hypofunction, and the decreased NR2C expression in NRG1 risk variant may cause a deficit in NMda receptor function.