J
Josef Frank
Researcher at Heidelberg University
Publications - 171
Citations - 23450
Josef Frank is an academic researcher from Heidelberg University. The author has contributed to research in topics: Genome-wide association study & Bipolar disorder. The author has an hindex of 41, co-authored 142 publications receiving 18096 citations.
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Journal ArticleDOI
Generation of three induced pluripotent stem cell lines carrying different variants of the BDNF (Val66Met) polymorphism.
TL;DR: One human-specific single nucleotide polymorphism (rs6265) in the BDNF gene causes a substitution of valine (Val) to methionine (Met) at codon 66 in the pro domain of the protein (Val66Met) as discussed by the authors .
Journal ArticleDOI
Common genetic variants associated with personality dimensions in the heidelberg cohort study of the elderly (heide)
Urs Heilbronner,Till F. M. Andlauer,Sergi Papiol,Monika Budde,Jana Strohmaier,Fabian Streit,Josef Frank,Manfred Amelang,Til Stürmer,Bertram Müller-Myhsok,Marcella Rietschel,Thomas G. Schulze +11 more
TL;DR: In this article, the authors used principal components factor analysis with varimax rotation to identify five latent personality dimensions (the Heidelberg Five), interpreted as emotional lability, lack of behavioral control, type-A-behavior, locus of control over disease, and psychoticism.
Posted ContentDOI
Evidence for a shared genetic contribution to loneliness and Borderline Personality Disorder
Anna Schulze,Fabian Streit,Lea Zillich,Swapnil Awasthi,Alisha S.M. Hall,Martin Jungkunz,Nikolaus Kleindienst,Josef Frank,C. E. Schwarze,Norbert Dahmen,B. Schott,MM Noethen,Arian Mobascher,Dan Rujescu,Klaus Lieb,Stefan Roepke,Sarah Herpertz,Christian Schmahl,Martin Bohus,Stephan Ripke,Marcella Rietschel,Stefanie Lis,S. Witt +22 more
TL;DR: In this paper , the authors investigated whether genetic predisposition for loneliness and BPD risk overlap and whether genetic risk for loneliness contributes to higher loneliness reported by BPD patients, using genome-wide genotype data.
Posted ContentDOI
Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder
Marisol Herrera-Rivero,Karina Gutiérrez-Fragoso,Anbupalam Thalamuthu,Azmeraw T. Amare,Mazda Adli,Kazufumi Akiyama,Nirmala Akula,Raffaella Ardau,Bárbara Arias,Jean-Michel Aubry,Lena Backlund,Frank Bellivier,Antoni Benabarre,Susanne Bengesser,Joanna M. Biernacka,Armin Birner,Micah Cearns,Pablo Cervantes,Hsi-Chung Chen,Caterina Chillotti,Sven Cichon,Scott R. Clark,Francesc Colom,Cristiana Cruceanu,Piotr M. Czerski,Nina Dalkner,Franziska Degenhardt,Maria Del Zompo,J. Raymond DePaulo,Bruno Etain,Peter Falkai,Ewa Ferensztajn-Rochowiak,Andreas J. Forstner,Josef Frank,Louise Frisén,Mark A. Frye,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Fernando S. Goes,Maria Grigoroiu-Serbanescu,Paul Grof,Ryota Hashimoto,Roland Hasler,Joanna Hauser,Urs Heilbronner,Stefan Herms,Per Hoffmann,Liping Hou,Yi-Hsiang Hsu,Stéphane Jamain,Esther Jiménez,Jean-Pierre Kahn,Layla Kassem,Tadafumi Kato,John R. Kelsoe,Sarah Kittel-Schneider,Po-Hsiu Kuo,Joachim Kurtz,Ichiro Kusumi,Barbara König,Gonzalo Laje,Mikael Landén,Catharina Lavebratt,Marion Leboyer,Susan G. Leckband,Mario Maj,Mirko Manchia,Cynthia Marie-Claire,Lina Martinsson,Michael McCarthy,Susan L. McElroy,Vincent Millischer,Marina Mitjans,Francis M. Mondimore,Palmiero Monteleone,Caroline M. Nievergelt,Thomas P. Novak,Markus M. Nöthen,C. Odonovan,Norio Ozaki,Sergi Papiol,Andrea Pfennig,Claudia Pisanu,James B. Potash,Andreas Reif,Eva Z. Reininghaus,Hélène Richard-Lepouriel,Gloria Roberts,Guy A. Rouleau,Janusz K. Rybakowski,Martin Schalling,Peter R. Schofield,Klaus Oliver Schubert,Eva C. Schulte,Barbara W. Schweizer,Giovanni Severino,Tatyana Shekhtman,Paul D. Shilling,Kazutaka Shimoda,Christian Simhandl,Claire Slaney,Alessio Squassina,Thomas Stamm,Pavla Stopkova,Fabian Streit,Fasil Tekola Ayele,Alfonso Tortorella,Gustavo Turecki,Julia Veeh,Eduard Vieta,Biju Viswanath,Stephanie H. Witt,Peter P. Zandi,Martin Alda,Michael Bauer,Francis J. McMahon,Philip B. Mitchell,Marcella Rietschel,Thomas G. Schulze,Bernhard T. Baune +120 more
TL;DR: In this article , the authors investigated the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical presentation of bipolar disorder (BP) and found a relatively weak association between immunity and clinically relevant features of BP at the genetic level.
Journal ArticleDOI
Differentially methylated regions in antidepressant response- a methylome-wide association study from the EMC trial
Jan Engelmann,Lea Zillich,Fabian Streit,Josef Frank,David B. Herzog,Sabrina Sordon,Marion Riemschneider,Marianne B. Müller,Marcella Rietschel,Klaus Lieb,S. Witt +10 more