J
Joshua A. Horwitz
Researcher at Rockefeller University
Publications - 36
Citations - 4370
Joshua A. Horwitz is an academic researcher from Rockefeller University. The author has contributed to research in topics: Virus & Antibody. The author has an hindex of 22, co-authored 34 publications receiving 3810 citations. Previous affiliations of Joshua A. Horwitz include Cornell University & Harvard University.
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Journal ArticleDOI
Beyond the Academic Journal: Unfreezing Misconceptions About Mental Illness and Gun Violence Through Knowledge Translation to Decision-Makers.
TL;DR: The recent passage of gun violence prevention legislation in California provides an example of successfully closing the knowledge translation gap between research and decision-making processes.
Posted ContentDOI
Structure of a rabies virus polymerase complex from electron cryo-microscopy
Joshua A. Horwitz,Simon Jenni,Stephen C. Harrison,Stephen C. Harrison,Sean P. J. Whelan,Sean P. J. Whelan +5 more
TL;DR: A complete structure of RABV L bound with its phosphoprotein cofactor (P) is described, determined by electron cryo-microscopy at 3.3 Å resolution, which suggests distinct template and product entry and exit pathways during transcription and replication.
Journal ArticleDOI
Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle
TL;DR: In this paper , the structure of intact, infectious VSV particles determined by cryogenic electron microscopy was reconstructed at 3.5 Å resolution, with lower resolution for the rounded tip.
Posted ContentDOI
HIV-1 Vpu restricts Fc-mediated effector functions in vivo
Jérémie Prévost,Sai Priya Anand,Jyothi K. Rajashekar,Jonathan Richard,Guillaume Goyette,Halima Medjahed,Gabrielle Gendron-Lepage,Hung-Ching Chen,Yao Chen,Joshua A. Horwitz,Michael W. Grunst,Susan Zolla-Pazner,Barton F. Haynes,Dennis R. Burton,Richard A. Flavell,Frank Kirchhoff,Beatrice H. Hahn,Amos B. Smith,Marzena Pazgier,Michel C. Nussenzweig,Priti Kumar,Andrés Finzi +21 more
TL;DR: It is found that restoring Vpu expression greatly reduces nnAb recognition of infected cells, rendering them resistant to ADCC responses, highlighting the importance of Vpu-mediated evasion of humoral responses.
Overcoming HIV pathways for escape using rationally-designed anti-HIV antibodies
Ron Diskin,D. Noah Sather,Paola Marcovecchio,Terri Lee,Anthony P. West,Han Gao,Florian Klein,Ari Halper-Stromberg,Joshua A. Horwitz,Michael S. Seaman,Leonidas Stamatatos,Michel C. Nussenzweig,Pamela J. Bjorkman +12 more
TL;DR: One mutant, 45-46m2, neutralizes 96% of HIV strains in a cross-clade panel and viruses isolated from an HIV-infected individual that are resistant to all other known bNAbs, making it the single most broad and potent anti-HIV antibody to date.