Joshua A. Horwitz

TL;DR: Three new potent neutralizing antibodies neutralize autologous HIV-1 strains and contribute to viral control in an HIV-2 controller who maintained low viral loads for 30 years after infection and developed broad and potent serologic activity against HIV- 1.

TL;DR: A replication-competent HIV-1 reporter virus that expresses a heterologous HA-tag on the surface of infected cells and virions is devised and data show that nnAbs can protect against and alter the course of HIV- 1 infection in vivo.

TL;DR: A computational tool was developed to help identify critical residues on the HIV-1 envelope protein whose natural variation affects antibody activity and confirmed that 8ANC195 represents a distinct class of glycan-dependent anti-HIV-1 antibody and validated the utility of computational analysis of neutralization panel data.

TL;DR: Mutating anti–HIV-1 broadly neutralizing antibodies increases their breadth and reduces pathways for viral escape through mutation.

TL;DR: It is found that frequently arising antibodies that normally fail to control HIV-1 infection can synergize with passively transferred bNAbs to prevent the emergence of bNAb viral escape variants.