J
Joshua D. Rabinowitz
Researcher at Princeton University
Publications - 418
Citations - 53550
Joshua D. Rabinowitz is an academic researcher from Princeton University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 102, co-authored 385 publications receiving 42192 citations. Previous affiliations of Joshua D. Rabinowitz include Stanford University & University of Pennsylvania.
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang,David W. White,Stefan Gross,Bryson D. Bennett,Mark A. Bittinger,Edward M. Driggers,Valeria Fantin,Hyun Gyung Jang,Shengfang Jin,Marie C. Keenan,Kevin Marks,Robert M. Prins,Patrick S. Ward,Katharine E. Yen,Linda M. Liau,Joshua D. Rabinowitz,Lewis C. Cantley,Craig B. Thompson,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Shinsan M. Su +20 more
TL;DR: It is shown that cancer-associated IDH1 mutations result in a new ability of the enzyme to catalyse the NADPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG), and that the excess 2HG which accumulates in vivo contributes to the formation and malignant progression of gliomas.
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The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
Patrick S. Ward,Jay P. Patel,David R. Wise,Omar Abdel-Wahab,Bryson D. Bennett,Hilary A. Coller,Justin R. Cross,Valeria Fantin,Cyrus V. Hedvat,Alexander E. Perl,Joshua D. Rabinowitz,Martin Carroll,Shinsan M. Su,Kim A. Sharp,Ross L. Levine,Craig B. Thompson +15 more
TL;DR: It is reported that tumor 2HG is elevated in a high percentage of patients with cytogenetically normal acute myeloid leukemia (AML), and AML patients with IDH mutations display a significantly reduced number of other well characterized AML-associated mutations and/or associated chromosomal abnormalities, potentially implicating IDH mutation in a distinct mechanism of AML pathogenesis.
Journal ArticleDOI
Autophagy and metabolism.
TL;DR: A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases and does have a downside, however—cancer cells exploit it to survive in nutrient-poor tumors.
Journal ArticleDOI
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli
Bryson D. Bennett,Elizabeth Kimball,Melissa Gao,Robin E. Osterhout,Stephen J. Van Dien,Joshua D. Rabinowitz +5 more
TL;DR: The data and analyses presented here highlight the ability to identify organizing metabolic principles from systems-level absolute metabolite concentration data, and facilitate efficient flux reversibility given thermodynamic and osmotic constraints.
Journal ArticleDOI
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Cosimo Commisso,Shawn M. Davidson,Rengin G. Soydaner-Azeloglu,Seth J. Parker,Jurre J. Kamphorst,Sean R. Hackett,Elda Grabocka,Michel Nofal,Jeffrey A. Drebin,Craig B. Thompson,Joshua D. Rabinowitz,Christian M. Metallo,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Dafna Bar-Sagi +14 more
TL;DR: In this paper, it was shown that Ras-transformed cells use macropinocytosis to transport extracellular protein into the cell, yielding amino acids including glutamine that can enter central carbon metabolism.